TSN Antibody

1. Translin and Trax control telomere-associated transcript levels in human cells in a telomere-specific fashion. PMID: 27183912
2. results indicate that UPF1 can dissociate miRNAs from their mRNA targets, making the miRNAs susceptible to Tudor-staphylococcal/micrococcal-like nuclease (TSN)-mediated miRNA decay. PMID: 28827400
3. These findings indicate that miRNA depletion in dicer deficiency is due to the combined loss of miRNA-generating activity and catabolic function of TN/TX. PMID: 25457613
4. this study argues against a mechanism by which translin octamers may "dissociate and reassemble" upon RNA binding and report a novel "open"-barrel structure of human translin revealing a feasible DNA/RNA entryway into the cavity. PMID: 25433126
5. The selectivity of PLCbeta toward certain genes lies in the rate at which the RNA is hydrolyzed by C3PO. PMID: 24338081
6. The data demonstrates that the configuration of translin and translin-RNA complexes in solution is a dimer of tetramers, which undergoes conformational transitions. PMID: 23980029
7. Translin B3 motif, corresponding to TRAX B3 residues, contributes towards its DNA binding activity. PMID: 22427937
8. C3PO endonuclease is an asymmetric octamer barrel consisting of six translin and two TRAX subunits which activates RISC by degrading the Ago2-nicked passenger strand of siRNA. PMID: 21552258
9. Sedimentation equilibrium studies using fluorescein-labeled single-stranded DNA support a model in which translin forms an annular structure of eight subunits, an oblate ellipsoid that binds single-stranded DNA at chromosomal breakpoints. PMID: 11705401
10. study of reactivity of two -SH groups and stidu of proximity of Cys-225 residues PMID: 11876655
11. At high enough concentrations, translin binds duplex DNA by selectively loading from the free ends, which apparently results in clamping of strands at the duplex ends. PMID: 12484770
12. The core protein of HCV can interact with translin protein. This can partly explain the molecular mechanism for hepatocellular carcinoma and lymphoma caused by HCV PMID: 12532453
13. TB-RBP post-transcriptionally stabilizes TRAX and both proteins are needed for normal cell proliferation PMID: 14711818
14. structure of human translin at 2.2 A resolution is reported in space group C222; translin forms a tetramer; this suggests that the multimerization of translin is flexible; the flexibility may be related to the binding to DNA/RNA PMID: 15039555
15. Results suggest that translin might be involved in the control of recombination at d(GT)n.d(AC)n microsatellites and in telomere maintenance. PMID: 15544804
16. Translin "chaperones" Trax and forms heteromeric complex that is DNA binding competent PMID: 15919079
17. Results describe a circular dichroism analysis of complexes formed between human translin and the microsatellite and telomeric oligodeoxynucleotides d(GT)(12) and d(TTAGGG)(5). PMID: 16218753
18. Human translin exhibits a stable octameric state and binds ssDNA/RNA/dsDNA targets, all of which get attenuated when GTP is added PMID: 16411762
19. Findings implicate abnormal dendritic trafficking of BDNF mRNA in the pathophysiology of neuropsychiatric disorders linked to the translin G196A mutation. PMID: 19805324

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HGNC: 12379

OMIM: 600575

KEGG: hsa:7247

STRING: 9606.ENSP00000374332

UniGene: Hs.75066