TSNAX Antibody

Code CSB-PA025144GA01HU
Size $600
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Product Details

Uniprot No.
Target Names
TSNAX
Alternative Names
Translin associated factor X antibody; Translin like protein antibody; Translin-associated factor X antibody; Translin-associated protein X antibody; TSNAX antibody; TSNAX_HUMAN antibody
Raised in
Rabbit
Species Reactivity
Human,Mouse,Rat
Immunogen
Human TSNAX
Immunogen Species
Homo sapiens (Human)
Isotype
IgG
Purification Method
Antigen Affinity Purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
Tested Applications
ELISA,IHC,IF
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
Acts in combination with TSN as an endonuclease involved in the activation of the RNA-induced silencing complex (RISC). Possible role in spermatogenesis.
Gene References into Functions
  1. TSNAX protein is known to form a brain enriched complex with translin, that can bind single-stranded DNA and RNA through which it is involved in protein regulation. PMID: 25043320
  2. High chimeric TSNAX-DISC1 resulting from intergenic splicing is associated with endometrial carcinoma. PMID: 25239642
  3. LIS1 and TSNAX genes are not associated with susceptibility to bipolar I disorder in Chinese Han population. PMID: 24928020
  4. Data show a novel role of phospholipase Cbeta1 (PLCbeta1) in gene regulation through translin-associated factor X (TRAX) association. PMID: 22889834
  5. Our results provide further evidence for sex-dependent effects of the TSNAX/DISC1 locus in the aetiology of schizophrenia and bipolar affective disorder PMID: 22673686
  6. TRAX binds to ssDNA and two regions in TRAX, designated TRAXB2 and TRAXB3, mediate nucleic acid binding activity of the trax-translin heteromeric complex. PMID: 22427937
  7. The results of this suggested an association between the TSNAX-DISC1 region and both forms of affective disorders. PMID: 19255581
  8. Results suggest that rs766288 in translin-associated factor X gene may play a role in the pathophysiology of female major depressive disorder in the Japanese population. PMID: 19760522
  9. TRAX is post-transcriptionally stabilized by TB-RBP and both proteins are needed for normal cell proliferation PMID: 14711818
  10. One region in TRAX showed weaker evidence for sex-specific associations of individual haplotypes with bipolar disorder in men. PMID: 15838535

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Subcellular Location
Cytoplasm, perinuclear region. Golgi apparatus. Nucleus.
Protein Families
Translin family
Database Links

HGNC: 12380

OMIM: 602964

KEGG: hsa:7257

STRING: 9606.ENSP00000355599

UniGene: Hs.13318

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