TSNAX Antibody

Datasheet

Code	CSB-PA858718LA01HU
Size	US$166
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Image	Western Blot Positive WB detected in: Hela whole cell lysate, Jurkat whole cell lysate, HL60 whole cell lysate, U87 whole cell lysate, 293T whole cell lysate, K562 whole cell lysate All lanes: TSNAX antibody at 2.5µg/ml Secondary Goat polyclonal to rabbit IgG at 1/50000 dilution Predicted band size: 34 kDa Observed band size: 34 kDa IHC image of CSB-PA858718LA01HU diluted at 1:500 and staining in paraffin-embedded human testis tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system. IHC image of CSB-PA858718LA01HU diluted at 1:500 and staining in paraffin-embedded human glioma performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system. Immunofluorescence staining of Hela cells with CSB-PA858718LA01HU at 1:166, counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeabilized using 0.2% Triton X-100 and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).
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Target Background

Product Details

Full Product Name

Rabbit anti-Homo sapiens (Human) TSNAX Polyclonal antibody

Uniprot No.

Q99598

Target Names

TSNAX

Alternative Names

Translin associated factor X antibody; Translin like protein antibody; Translin-associated factor X antibody; Translin-associated protein X antibody; TSNAX antibody; TSNAX_HUMAN antibody

Raised in

Rabbit

Species Reactivity

Human

Immunogen

Recombinant Human Translin-associated protein X protein (1-87AA)

Immunogen Species

Homo sapiens (Human)

Conjugate

Non-conjugated

The TSNAX Antibody (Product code: CSB-PA858718LA01HU) is Non-conjugated. For TSNAX Antibody with conjugates, please check the following table.

Conjugate	Product Code	Product Name	Application
HRP	CSB-PA858718LB01HU	TSNAX Antibody, HRP conjugated	ELISA
FITC	CSB-PA858718LC01HU	TSNAX Antibody, FITC conjugated
Biotin	CSB-PA858718LD01HU	TSNAX Antibody, Biotin conjugated	ELISA

Clonality

Polyclonal

Isotype

IgG

Purification Method

>95%, Protein G purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4

Form

Liquid

Tested Applications

ELISA, WB, IHC, IF

Recommended Dilution

Application	Recommended Dilution
WB	1:500-1:5000
IHC	1:500-1:1000
IF	1:50-1:200

Protocols

ELISA Protocol
Western Blotting(WB) Protocol
Immunohistochemistry (IHC) Protocol
Immunofluorescence (IF) Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Usage

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

Customer Reviews and Q&A

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Target Background

Function

Acts in combination with TSN as an endonuclease involved in the activation of the RNA-induced silencing complex (RISC). Possible role in spermatogenesis.

Gene References into Functions

TSNAX protein is known to form a brain enriched complex with translin, that can bind single-stranded DNA and RNA through which it is involved in protein regulation. PMID: 25043320
High chimeric TSNAX-DISC1 resulting from intergenic splicing is associated with endometrial carcinoma. PMID: 25239642
LIS1 and TSNAX genes are not associated with susceptibility to bipolar I disorder in Chinese Han population. PMID: 24928020
Data show a novel role of phospholipase Cbeta1 (PLCbeta1) in gene regulation through translin-associated factor X (TRAX) association. PMID: 22889834
Our results provide further evidence for sex-dependent effects of the TSNAX/DISC1 locus in the aetiology of schizophrenia and bipolar affective disorder PMID: 22673686
TRAX binds to ssDNA and two regions in TRAX, designated TRAXB2 and TRAXB3, mediate nucleic acid binding activity of the trax-translin heteromeric complex. PMID: 22427937
The results of this suggested an association between the TSNAX-DISC1 region and both forms of affective disorders. PMID: 19255581
Results suggest that rs766288 in translin-associated factor X gene may play a role in the pathophysiology of female major depressive disorder in the Japanese population. PMID: 19760522
TRAX is post-transcriptionally stabilized by TB-RBP and both proteins are needed for normal cell proliferation PMID: 14711818
One region in TRAX showed weaker evidence for sex-specific associations of individual haplotypes with bipolar disorder in men. PMID: 15838535

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Subcellular Location

Cytoplasm, perinuclear region. Golgi apparatus. Nucleus.

Protein Families

Translin family

Database Links

HGNC: 12380

OMIM: 602964

KEGG: hsa:7257

STRING: 9606.ENSP00000355599

UniGene: Hs.13318

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Antibody FAQs What Is an Antibody? How to Choose an Antibody for Scientific Research? The difference between primary antibody and secondary antibod The Meaning of Irregular Antibody Screening Tag Antibodies, Your Good Partner in Protein Research How to Choose the Loading Control Antibodies?

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301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)

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Address

7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA

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