TSNAX Antibody

Code CSB-PA858718LA01HU
Size US$166
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Image
  • Western Blot
    Positive WB detected in: Hela whole cell lysate, Jurkat whole cell lysate, HL60 whole cell lysate, U87 whole cell lysate, 293T whole cell lysate, K562 whole cell lysate
    All lanes: TSNAX antibody at 2.5µg/ml
    Secondary
    Goat polyclonal to rabbit IgG at 1/50000 dilution
    Predicted band size: 34 kDa
    Observed band size: 34 kDa

  • IHC image of CSB-PA858718LA01HU diluted at 1:500 and staining in paraffin-embedded human testis tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.

  • IHC image of CSB-PA858718LA01HU diluted at 1:500 and staining in paraffin-embedded human glioma performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.

  • Immunofluorescence staining of Hela cells with CSB-PA858718LA01HU at 1:166, counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeabilized using 0.2% Triton X-100 and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).

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Product Details

Full Product Name
Rabbit anti-Homo sapiens (Human) TSNAX Polyclonal antibody
Uniprot No.
Target Names
TSNAX
Alternative Names
Translin associated factor X antibody; Translin like protein antibody; Translin-associated factor X antibody; Translin-associated protein X antibody; TSNAX antibody; TSNAX_HUMAN antibody
Raised in
Rabbit
Species Reactivity
Human
Immunogen
Recombinant Human Translin-associated protein X protein (1-87AA)
Immunogen Species
Homo sapiens (Human)
Conjugate
Non-conjugated

The TSNAX Antibody (Product code: CSB-PA858718LA01HU) is Non-conjugated. For TSNAX Antibody with conjugates, please check the following table.

Available Conjugates
Conjugate Product Code Product Name Application
HRP CSB-PA858718LB01HU TSNAX Antibody, HRP conjugated ELISA
FITC CSB-PA858718LC01HU TSNAX Antibody, FITC conjugated
Biotin CSB-PA858718LD01HU TSNAX Antibody, Biotin conjugated ELISA
Clonality
Polyclonal
Isotype
IgG
Purification Method
>95%, Protein G purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Form
Liquid
Tested Applications
ELISA, WB, IHC, IF
Recommended Dilution
Application Recommended Dilution
WB 1:500-1:5000
IHC 1:500-1:1000
IF 1:50-1:200
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
Acts in combination with TSN as an endonuclease involved in the activation of the RNA-induced silencing complex (RISC). Possible role in spermatogenesis.
Gene References into Functions
  1. TSNAX protein is known to form a brain enriched complex with translin, that can bind single-stranded DNA and RNA through which it is involved in protein regulation. PMID: 25043320
  2. High chimeric TSNAX-DISC1 resulting from intergenic splicing is associated with endometrial carcinoma. PMID: 25239642
  3. LIS1 and TSNAX genes are not associated with susceptibility to bipolar I disorder in Chinese Han population. PMID: 24928020
  4. Data show a novel role of phospholipase Cbeta1 (PLCbeta1) in gene regulation through translin-associated factor X (TRAX) association. PMID: 22889834
  5. Our results provide further evidence for sex-dependent effects of the TSNAX/DISC1 locus in the aetiology of schizophrenia and bipolar affective disorder PMID: 22673686
  6. TRAX binds to ssDNA and two regions in TRAX, designated TRAXB2 and TRAXB3, mediate nucleic acid binding activity of the trax-translin heteromeric complex. PMID: 22427937
  7. The results of this suggested an association between the TSNAX-DISC1 region and both forms of affective disorders. PMID: 19255581
  8. Results suggest that rs766288 in translin-associated factor X gene may play a role in the pathophysiology of female major depressive disorder in the Japanese population. PMID: 19760522
  9. TRAX is post-transcriptionally stabilized by TB-RBP and both proteins are needed for normal cell proliferation PMID: 14711818
  10. One region in TRAX showed weaker evidence for sex-specific associations of individual haplotypes with bipolar disorder in men. PMID: 15838535

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Subcellular Location
Cytoplasm, perinuclear region. Golgi apparatus. Nucleus.
Protein Families
Translin family
Database Links

HGNC: 12380

OMIM: 602964

KEGG: hsa:7257

STRING: 9606.ENSP00000355599

UniGene: Hs.13318

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