TSPAN1 Antibody, FITC conjugated

Code CSB-PA025146LC01HU
Size US$166
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Product Details

Full Product Name
Rabbit anti-Homo sapiens (Human) TSPAN1 Polyclonal antibody
Uniprot No.
Target Names
TSPAN1
Alternative Names
TSPAN1; Tetraspanin-1; Tspan-1; Tetraspan NET-1; Tetraspanin TM4-C
Raised in
Rabbit
Species Reactivity
Human
Immunogen
Recombinant Human Tetraspanin-1 protein (110-211AA)
Immunogen Species
Homo sapiens (Human)
Conjugate
FITC
Clonality
Polyclonal
Isotype
IgG
Purification Method
>95%, Protein G purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
Form
Liquid
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Gene References into Functions
  1. miR4913p is frequently downregulated in OS. miR4913p suppressed OS cell growth and invasion. TSPAN1 was identified to be a novel target of miR4913p. Overexpressed TSPAN1 conferred OS cell growth and invasion. PMID: 28849017
  2. TSPAN1 has a role in prostate cancer progression and is a marker for early biochemical recurrence after radical prostatectomy PMID: 27556508
  3. The present study demonstrated that Tspan1 plays an important role in Pancreatic cancer carcinogenic progression, including migration and invasion. PMID: 26370588
  4. Restoration of TSPAN1 rescued the effects of miR-573 overexpression. Therefore, our findings suggest that the miR-573/TSPAN1 axis is important in the control of gastric carcinogenesis PMID: 26054975
  5. our current data demonstrate that miR-638 functions as a tumor suppressor in human colorectal carcinoma by inhibiting TSPAN1 PMID: 25301729
  6. TSPAN1 was proved to induce migration, and so up-regulation of TSPAN1 by miR-200a may explain why over-expressing miR-200a promotes NSCLC cells migration PMID: 23938385
  7. these data argue against a role for tetraspanin 1 as a genuine mediator of cell surface receptor signalling but rather document a role for tetraspanin 1 in the control of cervical cancer cell motility and invasion. PMID: 23754316
  8. data suggest that the NET-1 gene may play an important role in proliferation, migration and endocytosis in the development and progress of hepatocellular carcinoma PMID: 22378020
  9. Study provided the gene expression profile of HBV-related HCC and presented differential expression patterns of SATB-1, TM4SF-1 and ST-14 between cancerous and noncancerous tissues in patients with HBV-related HCC. PMID: 22088470
  10. These studies demonstrate for the first time that Tspan-1 is an interacting partner with human thiamine transporter-1 and that this interaction affects thiamine transporter-1 stability. PMID: 21836059
  11. TSPAN1 may be another important breast cancer suppressor gene belonging to the tetraspanin superfamily. PMID: 20680643
  12. RNAi-mediated downregulation of TSPAN1 expression significantly inhibits the proliferation and invasion of colon cancer cells in vitro. PMID: 21302622
  13. The overexpression of Tspan-1 was found in HCC tissues, positively correlated with clinical stage and negatively correlated with survival rate. PMID: 20890423
  14. Data show that Tspan-1-EGFP expressed in ovarian carcinoma cells was detected mainly in lysosomes, but also in the plasma membrane and in the ER. PMID: 19508227
  15. Overexpression of NET-1 is associated with undifferentiated squamous cell carcinoma of cervical neoplasms PMID: 12115476
  16. Detection of NET-1 gene expression in liver biopsy may provide useful information about the biological behavior of hepatocellular carcinoma. PMID: 17913940
  17. Overexpression of TSPAN1 and Ki67 was negatively correlated with carcinoma differentiation, and the overexpression of TSPAN1 and CD34 was positively correlated with infiltration and lymph node status of the tumor. PMID: 18822690
  18. describe the generation of Tspan-1-specific antibodies and immunohistochemical staining of different subtypes of ovarian carcinomas that revealed significant differences in Tspan-1 expression that was pronounced in mucinous and endometrioid tumors PMID: 19017553

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Subcellular Location
Lysosome membrane; Multi-pass membrane protein.
Protein Families
Tetraspanin (TM4SF) family
Database Links

HGNC: 20657

OMIM: 613170

KEGG: hsa:10103

STRING: 9606.ENSP00000361072

UniGene: Hs.38972

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