TSPEAR Antibody, HRP conjugated

Code CSB-PA848817LB01HU
Size US$166
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Product Details

Full Product Name
Rabbit anti-Homo sapiens (Human) TSPEAR Polyclonal antibody
Uniprot No.
Target Names
TSPEAR
Alternative Names
Thrombospondin-type laminin G domain and EAR repeat-containing protein antibody; TSEAR_HUMAN antibody; TSP-EAR antibody; TSPEAR antibody
Raised in
Rabbit
Species Reactivity
Human
Immunogen
Recombinant Human Thrombospondin-type laminin G domain and EAR repeat-containing protein (248-433AA)
Immunogen Species
Homo sapiens (Human)
Conjugate
HRP
Clonality
Polyclonal
Isotype
IgG
Purification Method
>95%, Protein G purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Form
Liquid
Tested Applications
ELISA
Protocols
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
Plays a critical role in tooth and hair follicle morphogenesis through regulation of the Notch signaling pathway. May play a role in development or function of the auditory system.
Gene References into Functions
  1. TSPEAR mutation is associated with tooth agenesis. PMID: 30046887
  2. using a luciferase-based reporter assay, we showed that TSPEAR knock-down is associated with decreased Notch signaling. In addition, NOTCH1 protein expression was reduced in patient scalp skin. Moreover, TSPEAR silencing in mouse hair follicle organ cultures was found to induce apoptosis in follicular epithelial cells, resulting in decreased hair bulb diameter PMID: 27736875
  3. TSPEAR expression is significantly downregulated in human masticatory mucosa during wound healing PMID: 28005267
  4. TSPEAR, cause disorders with auditory features: epilepsy, which can include auditory features in humans; audiogenic seizures in animals; and/or hearing impairments in humans and mice. PMID: 22678063
  5. The TSPEAR/C21orf29 promoter is activated by Trichostatin A (TSA) treatment according to promoter reporter assays in HEK 293 cells. PMID: 20494980

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Involvement in disease
Deafness, autosomal recessive, 98 (DFNB98)
Subcellular Location
Secreted. Cell surface. Cell projection, stereocilium.
Database Links

HGNC: 1268

OMIM: 612920

KEGG: hsa:54084

STRING: 9606.ENSP00000321987

UniGene: Hs.660703

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