TSPYL2 Antibody

1. Genome-wide polysome profiling shows that hCINAP selectively modulates cancer-associated translatome to promote malignancy. PMID: 27477389
2. Aortic CDA1 expression was downregulated approximately 70% within biopsies from human abdominal aortic aneurysms. PMID: 29311219
3. TSPY and TSPX exert opposing effects on the transactivation functions of AR and AR-Vs important for various physiological and disease processes sensitive to male sex hormone actions, thereby not only affecting the pathogenesis of male-specific prostate cancer but also likely contributing to sex differences in the health and diseases of man. PMID: 28169398
4. the extent of the duplicated regions in each case encompassing a minimum of three known disease genes TSPYL2, KDM5C and IQSEC2, is reported. PMID: 26059843
5. homozygous Asp3779Asn and a hemizygous Ile262Met mutations in the LRP2 and TSPYL2 genes, respectively, in a Pakistani family with two boys affected with mild nonsyndromic intellectual disability PMID: 26529358
6. Authors demonstrate that human coilin-interacting nuclear ATPase protein (hCINAP) is a novel negative regulator in NF-kappaB signaling by deactivating IkappaB kinase (IKK) complex. PMID: 26089539
7. TSPYL2 is an essential component of the REST/NRSF transcriptional complex for TGFbeta signaling activation PMID: 25613376
8. Atrial fibrillation can result in alterations in atrial structure and architecture that make the atrial myocardium more susceptible to the maintenance of the arrhythmia. PMID: 25142742
9. The oncogenic events leading to an ectopic activation of TSPY and/or inactivating mutation/epigenetic silencing of TSPX could collectively contribute to the sexual dimorphism(s) in HCC and related liver cancers in male-biased manners. PMID: 25017435
10. More importantly, RPS14 was specifically modified with NEDD8 and hCINAP inhibited RPS14 NEDDylation by recruiting NEDD8-specific protease 1 PMID: 23246961
11. hCINAP may not simply regulate nucleotide homeostasis, but may have broader functionality, including control of Cajal body assembly and disassembly PMID: 22038794
12. TSPX is principally expressed in Sertoli cells in the human testis. PMID: 21204751
13. knockdown of CINAP expression results in marked reduction of histone transcription, lower levels of U small nuclear RNAs (U1, U2, U4, and U5), and a loss of cell viability PMID: 20186459
14. hCINAP is a novel coilin-interacting protein encoded by a transcript from the transcription factor TAFIID32 locus PMID: 16079131
15. Overexpression of cell division autoantigen-1 (CDA1) slowed parasite growth and induced expression of bradyzoite-specific proteins. Results showed that changes in host cell transcription can influence the molecular environment for bradyzoite development. PMID: 17069459
16. CDA1 induces p53- and MEK/ERK1/2 MAPK-dependent expression of p21 by acting through the p53 responsive element in the p21 promoter and this contributes to its antiproliferative activity PMID: 17317670
17. a role for DENTT as a suppressor of the tumorigenic phenotype. PMID: 18381359
18. This paper characterizes monkey DENTT cDNA and makes a comparison with human and mouse DENTT PMID: 15823505

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HGNC: 24358

OMIM: 300564

KEGG: hsa:64061

STRING: 9606.ENSP00000364591

UniGene: Hs.136164