TTI2 Antibody, Biotin conjugated

Code CSB-PA764687LD01HU
Size US$166
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Product Details

Full Product Name
Rabbit anti-Homo sapiens (Human) TTI2 Polyclonal antibody
Uniprot No.
Target Names
TTI2
Alternative Names
C8orf41 antibody; CH041_HUMAN antibody; TELO2 interacting protein 2provided antibody; TTI2 antibody; Uncharacterized protein C8orf41 antibody
Raised in
Rabbit
Species Reactivity
Human
Immunogen
Recombinant Human TELO2-interacting protein 2 protein (159-264AA)
Immunogen Species
Homo sapiens (Human)
Conjugate
Biotin
Clonality
Polyclonal
Isotype
IgG
Purification Method
>95%, Protein G purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Form
Liquid
Tested Applications
ELISA
Protocols
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
Regulator of the DNA damage response (DDR). Part of the TTT complex that is required to stabilize protein levels of the phosphatidylinositol 3-kinase-related protein kinase (PIKK) family proteins. The TTT complex is involved in the cellular resistance to DNA damage stresses, like ionizing radiation (IR), ultraviolet (UV) and mitomycin C (MMC). Together with the TTT complex and HSP90 may participate in the proper folding of newly synthesized PIKKs.
Gene References into Functions
  1. The findings emphasises the role of the TTI2 gene in the etiology of intellectual disability. PMID: 23956177
  2. TTI1 and TTI2 protect cells from spontaneous DNA damage, and are required for the establishment of the intra-S and G2/M checkpoint. PMID: 20810650
Involvement in disease
Mental retardation, autosomal recessive 39 (MRT39)
Protein Families
TTI2 family
Database Links

HGNC: 26262

OMIM: 614426

KEGG: hsa:80185

STRING: 9606.ENSP00000353971

UniGene: Hs.742048

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