TTLL6 Antibody

Code CSB-PA818727LA01HU
Size US$166
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Image
  • Western Blot
    Positive WB detected in: U87 whole cell lysate
    All lanes: TTLL6 antibody at 5µg/ml
    Secondary
    Goat polyclonal to rabbit IgG at 1/50000 dilution
    Predicted band size: 97, 65 kDa
    Observed band size: 97 kDa

  • IHC image of CSB-PA818727LA01HU diluted at 1:500 and staining in paraffin-embedded human testis tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.

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Product Details

Full Product Name
Rabbit anti-Homo sapiens (Human) TTLL6 Polyclonal antibody
Uniprot No.
Target Names
TTLL6
Alternative Names
TTLL6 antibody; TTL.6 antibody; Tubulin polyglutamylase TTLL6 antibody; EC 6.-.-.- antibody; Tubulin--tyrosine ligase-like protein 6 antibody
Raised in
Rabbit
Species Reactivity
Human
Immunogen
Recombinant Human Tubulin polyglutamylase TTLL6 protein (121-310AA)
Immunogen Species
Homo sapiens (Human)
Conjugate
Non-conjugated

The TTLL6 Antibody (Product code: CSB-PA818727LA01HU) is Non-conjugated. For TTLL6 Antibody with conjugates, please check the following table.

Available Conjugates
Conjugate Product Code Product Name Application
HRP CSB-PA818727LB01HU TTLL6 Antibody, HRP conjugated ELISA
FITC CSB-PA818727LC01HU TTLL6 Antibody, FITC conjugated
Biotin CSB-PA818727LD01HU TTLL6 Antibody, Biotin conjugated ELISA
Clonality
Polyclonal
Isotype
IgG
Purification Method
>95%, Protein G purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
Form
Liquid
Tested Applications
ELISA, WB, IHC
Recommended Dilution
Application Recommended Dilution
WB 1:500-1:5000
IHC 1:500-1:1000
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
Polyglutamylase which modifies both tubulin and non-tubulin proteins, generating alpha-linked polyglutamate side chains on the gamma-carboxyl group of specific glutamate residues of target proteins. Preferentially mediates ATP-dependent long polyglutamate chain elongation over the initiation step of the polyglutamylation reaction. Preferentially modifies the alpha-tubulin tail over a beta-tail. Promotes tubulin polyglutamylation which stimulates spastin/SPAST-mediated microtubule severing, thereby regulating microtubule functions. Mediates microtubule polyglutamylation in primary cilia axoneme, which is important for ciliary structural formation and motility. Mediates microtubule polyglutamylation in motile cilia, necessary for the regulation of ciliary coordinated beating. Polyglutamylates non-tubulin protein nucleotidyltransferase CGAS, leading to CGAS DNA-binding inhibition, thereby preventing antiviral defense response.
Subcellular Location
Cytoplasm. Cytoplasm, cytoskeleton. Cytoplasm, cytoskeleton, cilium axoneme. Cytoplasm, cytoskeleton, cilium basal body.
Protein Families
Tubulin--tyrosine ligase family
Database Links

HGNC: 26664

OMIM: 610849

KEGG: hsa:284076

STRING: 9606.ENSP00000377043

UniGene: Hs.91930

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