TWF1 Antibody

Datasheet

Code	CSB-PA622511LA01HU
Size	US$166
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Image	Immunohistochemistry of paraffin-embedded human pancreatic tissue using CSB-PA622511LA01HU at dilution of 1:100 Immunofluorescent analysis of Hela cells using CSB-PA622511LA01HU at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)
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Target Background

Product Details

Full Product Name

Rabbit anti-Homo sapiens (Human) TWF1 Polyclonal antibody

Uniprot No.

Q12792

Target Names

TWF1

Alternative Names

A6 antibody; A6 protein tyrosine kinase antibody; MGC105817 antibody; MGC23788 antibody; MGC41876 antibody; Protein A6 antibody; Protein tyrosine kinase 9 antibody; PTK9 antibody; PTK9 protein tyrosine kinase 9 antibody; TWF 1 antibody; twf1 antibody; TWF1_HUMAN antibody; Twinfilin 1 antibody; Twinfilin actin binding protein, homolog 1 antibody; Twinfilin antibody; Twinfilin, actin-binding protein, homolog 1 (Drosophila) antibody; Twinfilin, Drosophila, homolog of, 1 antibody; Twinfilin-1 antibody

Raised in

Rabbit

Species Reactivity

Human

Immunogen

Recombinant Human Twinfilin-1 protein (199-252AA)

Immunogen Species

Homo sapiens (Human)

Conjugate

Non-conjugated

The TWF1 Antibody (Product code: CSB-PA622511LA01HU) is Non-conjugated. For TWF1 Antibody with conjugates, please check the following table.

Conjugate	Product Code	Product Name	Application
HRP	CSB-PA622511LB01HU	TWF1 Antibody, HRP conjugated	ELISA
FITC	CSB-PA622511LC01HU	TWF1 Antibody, FITC conjugated
Biotin	CSB-PA622511LD01HU	TWF1 Antibody, Biotin conjugated	ELISA

Clonality

Polyclonal

Isotype

IgG

Purification Method

>95%, Protein G purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4

Form

Liquid

Tested Applications

ELISA, IHC, IF

Recommended Dilution

Application	Recommended Dilution
IHC	1:20-1:200
IF	1:50-1:200

Protocols

ELISA Protocol
Immunohistochemistry (IHC) Protocol
Immunofluorescence (IF) Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Usage

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

Customer Reviews and Q&A

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Target Background

Function

Actin-binding protein involved in motile and morphological processes. Inhibits actin polymerization, likely by sequestering G-actin. By capping the barbed ends of filaments, it also regulates motility. Seems to play an important role in clathrin-mediated endocytosis and distribution of endocytic organelles.

Gene References into Functions

Univariate Cox regression analysis showed high expression of TWF1 to be independent prognostic indicator involved in overall survival and recurrence-free survival in lung adenocarcinoma, but not in lung squamous cell carcinoma PMID: 30391462
TWF1 and VIM are required for miR-30c to regulate breast cancer cell invasion. PMID: 23224145
An interleukin-6 family member, interleukin-11 is identified as a secondary target of twinfilin 1 in the microRNA-30c signalling pathway. PMID: 23340433
protein overexpression promotes cardiomyocyte hypertrophy PMID: 20571053
These data suggest that the association with an actin monomer induces a first-order conformational change within the twinfilin molecule. PMID: 12429826
mammals have two twinfilin isoforms, which are differentially expressed and regulated through distinct cellular signaling pathways PMID: 12807912

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Involvement in disease

Defects in TWF1 has been found in a patient with isolated coloboma, a defect of the eye characterized by the absence of ocular structures due to abnormal morphogenesis of the optic cup and stalk, and the fusion of the fetal fissure (optic fissure). Isolated colobomas may be associated with an abnormally small eye (microphthalmia) or small cornea.

Subcellular Location

Cytoplasm. Cytoplasm, cytoskeleton.

Protein Families

Actin-binding proteins ADF family, Twinfilin subfamily

Tissue Specificity

Expressed at high levels in the colon, testis, ovary, prostate and lung. Expressed at lower levels in the brain, bladder and heart. Not detected in liver.

Database Links

HGNC: 9620

OMIM: 610932

KEGG: hsa:5756

STRING: 9606.ENSP00000449428

UniGene: Hs.189075

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Service

Phage Display Service

Antibody Service

Protein Service

Gene Synthesis Service

Oligo Synthesis Service

Antibody FAQs What Is an Antibody? How to Choose an Antibody for Scientific Research? The difference between primary antibody and secondary antibod The Meaning of Irregular Antibody Screening Tag Antibodies, Your Good Partner in Protein Research How to Choose the Loading Control Antibodies?

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Target Therapy

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301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)

[email protected]

Address

7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA

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