TWF1

TWF1 encodes the Twinfilin-1 protein, also commonly known as Twinfilin-1 homolog. This protein is a key player in actin dynamics regulation. It binds to actin monomers and inhibits their addition to the growing ends of actin filaments, thus influencing cell motility, shape, and division. It is involved in the Rho signaling pathway, which is crucial for cytoskeleton organization.
Disruptions in TWF1 function have been associated with various diseases, especially cancer, where abnormal cell motility and invasion are hallmarks. In terms of drug development, researchers are exploring potential small - molecule inhibitors targeting TWF1 to modulate actin dynamics as a new strategy for cancer treatment, but this area still requires further in - depth research.