Tph1 Antibody, FITC conjugated

1. Both gut-specific Tph1 knockout mice and liver-specific Htr2a knockout mice are resistant to high fat diet-induced hepatic steatosis, without affecting systemic energy homeostasis. PMID: 30446669
2. Data suggest that central melanocortin-4 receptor (MC4-R) and tryptophan hydroxylase (TPH) are involved in the efferent neuronal control of the kidneys. PMID: 27626491
3. Prolactin-induced Tph1 expression. PMID: 26136513
4. Tph1-deficient mice fed a high-fat diet (HFD) are protected from obesity, insulin resistance and nonalcoholic fatty liver disease (NAFLD) while exhibiting greater energy expenditure by brown adipose tissue. PMID: 25485911
5. Lack of tryptophan hydroxylase-1 in mice results in gait abnormalities. PMID: 23516593
6. ZBP-89 directly binds to the Tph1 promoter, which is required for its basal and butyrate-inducible expression. PMID: 23395646
7. TPH1 deficiency or inhibition reduces allergic airway inflammation. Platelet-derived 5-HT is pivotal in AAI and lack of 5-HT leads to impaired Th2 priming capacity of bone marrow dendritic cells. PMID: 23328530
8. Data indicate that tryptophan hydroxylase (Tph)1-deficient mice, lacking non-neuronal serotonin, showed mild leukocytosis. PMID: 23243271
9. Data show that Tph-1 (tryptophan hydroxylase-1) is a potent regulator of immunity. PMID: 23008335
10. Parallel to Tph1 mRNA and protein induction, islet serotonin content increased to a peak level that was 200-fold higher than basal. Interestingly, only a subpopulation of the beta cells was serotonin-positive in vitro and in vivo. PMID: 20938637
11. nonneuronal tph1 gene has a role in cardiac function with peripheral serotonin PMID: 14597720
12. Review. TPH1 is expressed in the pineal gland and the enterochromaffin cells. Loss of TPH1 gene expression, and thus of peripheral 5-HT, leads to a cardiac dysfunction phenotype. PMID: 15146950
13. estrogen receptor-beta is responsible for mediating estrogen regulated tryptophan hydroxylase-1 expression in the murine dorsal raphe nucleus PMID: 15820717
14. TPH1 is expressed preferentially during late developmental brain stages. Low raphe nuclei 5-HT contents were seen during development in NZW & SWR mice with common functional polymorphisms in TPH1. TPH1 may influence behavior later in life. PMID: 16407550
15. TPH1 is the predominant form expressed in pineal gland and with a molecular weight of 51 kDa. PMID: 16581041
16. Tryptophan hydroxylase 1 and peripheral serotonin play an essential role in the development of hypoxia-induced elevations in pulmonary pressures and hypoxia-induced pulmonary vascular remodeling. PMID: 17130306
17. Tph1 knockout mice used to show that serotonin plays a role in the pathogenesis of steatohepatitis. PMID: 17681180
18. Cardiomyopathy is more severe in adult Tph1 knockout mice born to homozygous mothers than to heterozygous mothers. PMID: 18267982
19. In a genetic model of serotonin deficiency (Tph1(-/-)) in mice, serotonin shown to be crucial for the growth of s.c. colon cancer allografts in vivo. PMID: 18593914
20. substantially reduced peripheral 5-HT levels in Tph1/Tph2 double knockout, but not TPH2KO mice PMID: 18923670
21. In mice no significant TPH1 expression was detected in the brain. PMID: 19181488

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KEGG: mmu:21990

STRING: 10090.ENSMUSP00000037752

UniGene: Mm.248684