UBE2E3 Antibody

Code CSB-PA025450GA01HU
Size $600
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Product Details

Uniprot No.
Target Names
Alternative Names
Homologous to yeast UBC4/5 antibody; UB2E3_HUMAN antibody; UBC E4 antibody; Ubc M2 antibody; UBC4/5 homolog antibody; UBCE 4 antibody; UBCE4 antibody; UBCH 9 antibody; UbcH9 antibody; UbcM2 antibody; UBE2 E3 antibody; UBE2E3 antibody; Ubiquitin carrier protein antibody; Ubiquitin carrier protein E3 antibody; Ubiquitin conjugating enzyme E2 23 kDa antibody; Ubiquitin conjugating enzyme E2 E3 antibody; Ubiquitin conjugating enzyme E2E 3 (homologous to yeast UBC4/5) antibody; Ubiquitin conjugating enzyme E2E 3 (UBC4/5 homolog, yeast antibody; Ubiquitin conjugating enzyme E2E 3 antibody; Ubiquitin conjugating enzyme UBCH 9 antibody; Ubiquitin conjugating enzyme UBCH9 antibody; Ubiquitin protein ligase antibody; Ubiquitin protein ligase E3 antibody; Ubiquitin-conjugating enzyme E2 E3 antibody; Ubiquitin-conjugating enzyme E2-23 kDa antibody; Ubiquitin-protein ligase E3 antibody
Raised in
Species Reactivity
Human UBE2E3
Immunogen Species
Homo sapiens (Human)
Purification Method
Antigen Affinity purified
It differs from different batches. Please contact us to confirm it.
PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
Tested Applications
Troubleshooting and FAQs
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro catalyzes 'Lys-11'- and 'Lys-48'-, as well as 'Lys-63'-linked polyubiquitination. Participates in the regulation of transepithelial sodium transport in renal cells. May be involved in cell growth arrest.
Gene References into Functions
  1. Cells depleted of UBE2E3 become senescent in the absence of overt DNA damage and have a distinct senescence-associated secretory phenotype, increased mitochondrial and lysosomal mass, an increased sensitivity to mitochondrial and lysosomal poisons, and an increased basal autophagic flux. PMID: 29879550
  2. Data indicate that ubiquitin-conjugating enzyme UBE2E3 and importin 11 (Imp-11)promote the nuclear accumulation and activity of transcription factor NF-E2 (Nrf2) by restricting the transcription factor from partitioning to the mitochondria. PMID: 25378586
  3. UBE2E3 is essential for the proliferation of RPE-1 cells and is downregulated during RPE layer maturation in the developing mouse eye. PMID: 18614808
Subcellular Location
Nucleus. Cytoplasm. Note=Shuttles between the nucleus and cytoplasm in a IPO11-dependent manner.
Protein Families
Ubiquitin-conjugating enzyme family
Tissue Specificity
Ubiquitously expressed at low levels. Highly expressed in skeletal muscle.
Database Links

HGNC: 12479

OMIM: 604151

KEGG: hsa:10477

STRING: 9606.ENSP00000376215

UniGene: Hs.470804

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