UCHL3 Antibody

1. The authors find that UCHL3 regulates COPS5-dependent deneddylation of Cullin1, which is an essential component of SCF(beta-TrCP) complex and associated with SCF(beta-TrCP) activities. The authors further demonstrate that UCHL3 upregulates the levels of SCF(beta-TrCP) substrates including IFN-I receptor IFNAR1, which enhances IFN-I mediated signaling pathway and antiviral activity. PMID: 28583475
2. Study demonstrated positive correlations between the level and activity of UCHL3 and sperm characteristics and function suggesting that UCHL3 may play a role in male infertility. PMID: 27780264
3. Using a series of engineered protein substrates, which are similar in size yet differ in secondary structure, we demonstrate that thermal stability is a key factor that significantly affects UCH-L3 hydrolysis. PMID: 25369561
4. UCH-L3 is a novel regulator of epithelial-mesenchymal transition and cell migration in prostate cancer cells. PMID: 25194810
5. Data identified of UCHL3 as an essential deubiquitinase in adipogenesis. PMID: 22679485
6. impaired UCH-L3 function may contribute to the accumulation of full length UBB(+1) in various pathologie PMID: 21762696
7. 1.45 A resolution crystal structure of human UCH-L3 in complex with the inhibitor ubiquitin vinylmethylester, an inhibitor that forms a covalent adduct with the active site cysteine of ubiquitin-specific proteases PMID: 15531586
8. Upregulation of UCH-L3 is associated with Uterine Cervical Neoplasms PMID: 16402389
9. Substrate filtering by the active site crossover loop in UCHL3 revealed by sortagging and gain-of-function mutations. PMID: 19047059
10. These results indicate that mono-Ub and Ub dimers may regulate the enzymatic functions of UCH-L1 and UCH-L3, respectively, in vivo. PMID: 19154770
11. Untangling the folding mechanism of the 5(2)-knotted protein UCH-L3 PMID: 19476499
12. identification and the sequence-specific assignments for 186 out of the 218 UCH-L3 (230 less 12 prolines) backbone 15N and amide proton resonances PMID: 19636824

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HGNC: 12515

OMIM: 603090

KEGG: hsa:7347

STRING: 9606.ENSP00000366819

UniGene: Hs.162241