UHMK1 Antibody

Datasheet

Code	CSB-PA840554LA01HU
Size	US$166
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Image	Western Blot Positive WB detected in: Mouse brain tissue All lanes: UHMK1 antibody at 3μg/ml Secondary Goat polyclonal to rabbit IgG at 1/50000 dilution Predicted band size: 47, 39, 40 kDa Observed band size: 47 kDa Immunohistochemistry of paraffin-embedded human prostate tissue using CSB-PA840554LA01HU at dilution of 1:100 Immunofluorescent analysis of PC-3 cells using CSB-PA840554LA01HU at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)
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Product Details
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Target Background

Product Details

Full Product Name

Rabbit anti-Homo sapiens (Human) UHMK1 Polyclonal antibody

Uniprot No.

Q8TAS1

Target Names

UHMK1

Alternative Names

DKFZp434C1613 antibody; FLJ23015 antibody; kinase interacting with leukemia-associated gene (stathmin) antibody; Kinase interacting with stathmin antibody; KIS antibody; KIS protein kinase antibody; KIST antibody; OTTHUMP00000029529 antibody; P-CIP2 antibody; Serine threonine protein kinase Kist antibody; Serine/threonine-protein kinase Kist antibody; U2AF homology motif (UHM) kinase 1 antibody; U2AF homology motif kinase 1 antibody; UHMK1 antibody; UHMK1_HUMAN antibody

Raised in

Rabbit

Species Reactivity

Human, Mouse

Immunogen

Recombinant Human Serine/threonine-protein kinase Kist protein (183-385AA)

Immunogen Species

Homo sapiens (Human)

Conjugate

Non-conjugated

The UHMK1 Antibody (Product code: CSB-PA840554LA01HU) is Non-conjugated. For UHMK1 Antibody with conjugates, please check the following table.

Conjugate	Product Code	Product Name	Application
HRP	CSB-PA840554LB01HU	UHMK1 Antibody, HRP conjugated	ELISA
FITC	CSB-PA840554LC01HU	UHMK1 Antibody, FITC conjugated
Biotin	CSB-PA840554LD01HU	UHMK1 Antibody, Biotin conjugated	ELISA

Clonality

Polyclonal

Isotype

IgG

Purification Method

>95%, Protein G purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4

Form

Liquid

Tested Applications

ELISA, WB, IHC, IF

Recommended Dilution

Application	Recommended Dilution
WB	1:500-1:5000
IHC	1:20-1:200
IF	1:50-1:200

Protocols

ELISA Protocol
Western Blotting(WB) Protocol
Immunohistochemistry (IHC) Protocol
Immunofluorescence (IF) Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Customer Reviews and Q&A

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Target Background

Function

Upon serum stimulation, phosphorylates CDKN1B/p27Kip1, thus controlling CDKN1B subcellular location and cell cycle progression in G1 phase. May be involved in trafficking and/or processing of RNA.

Gene References into Functions

UHMK1 plays a role in hematopoietic cell differentiation and suppression of autonomous clonal growth of leukemia cells. PMID: 29307747
genome-wide association study identified the UHMK1 gene as a novel bone mineral density locus specific to East Asians. PMID: 27424934
The contribution of UHMK1 gene in schizophrenia susceptibility, was explored. PMID: 21399567
We identify the kinase responsible for S10 phosphorylation as human kinase interacting stathmin (hKIS) and show that it regulates cell cycle progression in response to mitogens. PMID: 12093740
KIS gene was overexpressed in NF1-associated plexiform neurofibromas and malignant peripheral nerve sheath tumors (MPNSTs) as compared to dermal neurofibroma which suggests a possible implication of KIS in the genesis of NF1-associated tumors. PMID: 12782393
These results provide preliminary evidence that the UHMK1 gene increases susceptibility to schizophrenia. Further confirmation in adequately powered samples is needed. PMID: 16978587
KIS promoter is activated by serum-responsive GABP binding to Ets-binding sites which leads to KIS gene expression, cell migration, and cell cycle progression PMID: 17726090
Results show that KIS is a direct transcriptional target of FoxM1. PMID: 17984092
Overexpression of KIS protein kinase is associated with acute myelogenous leukemia, myelodysplastic syndrome and acute lymphoblastic leukemia PMID: 18384876
The association between UHMK1 and schizophrenia is confirmed. PMID: 18414510
KIS is expressed in neurons, and its encoded protein is localised to the nucleus and cytoplasm. No difference in KIS expression was found between schizophrenics and controls or in the lymphoblast cell lines. PMID: 19747464
A follow up article showing further association between markers in UHMK1 and schizophrenia in a London based sample. Association replicated in an independent Scottish sample. PMID: 18414510
Evidence indicating that UHMK1 may be a candidate susceptibility gene for Schizophrenia in the British population. UHMK1 is situated between previously implicated genes RGS4 and NOS1AP. PMID: 16978587

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Subcellular Location

Nucleus.

Protein Families

Protein kinase superfamily, Ser/Thr protein kinase family

Tissue Specificity

Widely expressed, with highest levels in skeletal muscle, kidney, placenta and peripheral blood leukocytes.

Database Links

HGNC: 19683

OMIM: 608849

KEGG: hsa:127933

STRING: 9606.ENSP00000420270

UniGene: Hs.127310

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Antibody FAQs What Is an Antibody? How to Choose an Antibody for Scientific Research? The difference between primary antibody and secondary antibod The Meaning of Irregular Antibody Screening Tag Antibodies, Your Good Partner in Protein Research How to Choose the Loading Control Antibodies?

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301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)

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Address

7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA

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