ULK2 Antibody, FITC conjugated

Datasheet
Code CSB-PA811629LC01HU
Size US$299
Uniprot No. Q8IYT8
Immunogen Recombinant Human Serine/threonine-protein kinase ULK2 protein (211-276AA)
Raised in Rabbit
Species Reactivity Human
Tested Applications ELISA
Relevance Serine/threonine-protein kinase involved in autophagy in response to starvation. Acts upstream of phosphatidylinositol 3-kinase PIK3C3 to regulate the formation of autophagophores, the precursors of autophagosomes. Part of regulatory feedback loops in autophagy: acts both as a downstream effector and a negative regulator of mammalian target of rapamycin complex 1 (mTORC1) via interaction with RPTOR. Activated via phosphorylation by AMPK, also acts as a negative regulator of AMPK through phosphorylation of the AMPK subunits PRKAA1, PRKAB2 and PRKAG1. May phosphorylate ATG13/KIAA0652, FRS2, FRS3 and RPTOR; however such data need additional evidences. Not involved in ammonia-induced autophagy or in autophagic response of cerebellar granule neurons (CGN) to low potassium concentration. Plays a role early in neuronal differentiation and is required for granule cell axon formation: may govern axon formation via Ras-like GTPase signaling and through regulation of the Rab5-mediated endocytic pathways within developing axons.
Form Liquid
Conjugate FITC
Storage Buffer Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Purification Method >95%, Protein G purified
Isotype IgG
Clonality Polyclonal
Alias Serine/threonine-protein kinase ULK2 (EC 2.7.11.1) (Unc-51-like kinase 2), ULK2, KIAA0623
Immunogen Species Homo sapiens (Human)
Protocols ELISA Protocol
Research Area Signal Transduction
Target Names ULK2
Storage Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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Function Serine/threonine-protein kinase involved in autophagy in response to starvation. Acts upstream of phosphatidylinositol 3-kinase PIK3C3 to regulate the formation of autophagophores, the precursors of autophagosomes. Part of regulatory feedback loops in autophagy
Subcellular Location Cytoplasmic vesicle membrane, Peripheral membrane protein
Protein Families Protein kinase superfamily, Ser/Thr protein kinase family, APG1/unc-51/ULK1 subfamily
Database Links

HGNC: 13480

OMIM: 608650

KEGG: hsa:9706

STRING: 9606.ENSP00000354877

UniGene: Hs.168762

Pathway mTOR signaling pathway
Autophagy

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