UNC45A Antibody

1. Whole-exome sequencing of all affected individuals and their parents identified biallelic mutations in Unc-45 Myosin Chaperone A (UNC45A) as a likely driver for cholestasis, congenital diarrhea, impaired hearing, and bone fragility. PMID: 29429573
2. UNC-45a promotes generation of contractile actomyosin bundles through synchronized non-muscle myosin II folding and filament-assembly activities. PMID: 29055011
3. Results provide novel insights into the molecular mechanisms of neurite growth and define UNC-45A as a novel and master regulator of NMII-mediated cellular processes in neurons. PMID: 28356421
4. UNC-45A is a crucial component in regulating human NK cell cytoskeletal dynamics via promoting the formation of actomyosin complexes. PMID: 26438524
5. Findings identify a novel centrosomal function for UNC45A and its role in cell proliferation and tumorigenesis. PMID: 25444911
6. The authors found that UNC-45A is alternatively expressed at the mRNA and protein levels as two isoforms and that the two isoforms differ only by a proline-rich 15-amino-acid sequence near the amino-terminus. PMID: 21802425
7. GCUNC-45 is a novel modulator of progesterone receptor chaperoning by hsp90. PMID: 16478993
8. elevated GC UNC-45 protein expression in ovarian carcinoma proliferation and metastasis. PMID: 17872978
9. GCUNC45 is required for the normal cellular distribution of Hsp90beta, but not Hsp90alpha. PMID: 18285346

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HGNC: 30594

OMIM: 611219

KEGG: hsa:55898

STRING: 9606.ENSP00000407487

UniGene: Hs.389461