USP12 Antibody

Datasheet

Code	CSB-PA025699LA01HU
Size	US$166
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Image	Western blot All lanes: USP12 antibody at 2µg/ml + Mouse liver tissue Secondary Goat polyclonal to rabbit IgG at 1/10000 dilution Predicted band size: 43 kDa Observed band size: 43 kDa
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Product Details
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Target Background

Product Details

Full Product Name

Rabbit anti-Homo sapiens (Human) USP12 Polyclonal antibody

Uniprot No.

O75317

Target Names

USP12

Alternative Names

Deubiquitinating enzyme 12 antibody; OTTHUMP00000042337 antibody; UBH 1 antibody; UBH1 antibody; Ubiquitin carboxyl terminal hydrolase 12 antibody; Ubiquitin carboxyl-terminal hydrolase 12 antibody; Ubiquitin hydrolyzing enzyme 1 antibody; Ubiquitin specific peptidase 12 antibody; Ubiquitin specific processing protease 12 antibody; Ubiquitin specific protease 12 like 1 antibody; Ubiquitin thioesterase 12 antibody; Ubiquitin thiolesterase 12 antibody; Ubiquitin-hydrolyzing enzyme 1 antibody; Ubiquitin-specific-processing protease 12 antibody; UBP12_HUMAN antibody; USP 12 antibody; Usp12 antibody; USP12L1 antibody

Raised in

Rabbit

Species Reactivity

Human, Mouse

Immunogen

Recombinant Human Ubiquitin carboxyl-terminal hydrolase 12 protein (1-370AA)

Immunogen Species

Homo sapiens (Human)

Conjugate

Non-conjugated

The USP12 Antibody (Product code: CSB-PA025699LA01HU) is Non-conjugated. For USP12 Antibody with conjugates, please check the following table.

Conjugate	Product Code	Product Name	Application
HRP	CSB-PA025699LB01HU	USP12 Antibody, HRP conjugated	ELISA
FITC	CSB-PA025699LC01HU	USP12 Antibody, FITC conjugated
Biotin	CSB-PA025699LD01HU	USP12 Antibody, Biotin conjugated	ELISA

Clonality

Polyclonal

Isotype

IgG

Purification Method

Antigen Affinity Purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4

Form

Liquid

Tested Applications

ELISA, WB

Recommended Dilution

Application	Recommended Dilution
WB	1:200-1:1000

Protocols

ELISA Protocol
Western Blotting(WB) Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Usage

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

Customer Reviews and Q&A

■ Customer Reviews

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Target Background

Function

Deubiquitinating enzyme. Has almost no deubiquitinating activity by itself and requires the interaction with WDR20 and WDR48 to have a high activity. Not involved in deubiquitination of monoubiquitinated FANCD2. In complex with WDR48, acts as a potential tumor suppressor by positively regulating PHLPP1 stability.

Gene References into Functions

Usp12 deubiquitylates and prevents lysosomal degradation of LAT and Trat1 to maintain the proximal TCR complex for the duration of signaling. PMID: 26811477
Usp12 directly deubiquitinates and stabilises the Akt phosphatases PHLPP and PHLPPL resulting in decreased levels of active pAkt. PMID: 25216524
our results reveal WDR48 and USP12 as novel PHLPP1 regulators and potential suppressors of tumor cell survival PMID: 24145035
Usp12 acts in a pro-proliferative manner by stabilizing AR and enhancing its cellular function. PMID: 24056413
The ubiquitin-specific protease 12 (USP12) is a negative regulator of notch signaling acting on notch receptor trafficking toward degradation. PMID: 22778262

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Protein Families

Peptidase C19 family, USP12/USP46 subfamily

Database Links

HGNC: 20485

OMIM: 603091

KEGG: hsa:219333

STRING: 9606.ENSP00000282344

UniGene: Hs.42400

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Antibody FAQs What Is an Antibody? How to Choose an Antibody for Scientific Research? The difference between primary antibody and secondary antibod The Meaning of Irregular Antibody Screening Tag Antibodies, Your Good Partner in Protein Research How to Choose the Loading Control Antibodies?

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301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)

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Address

7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA

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