USP24 Antibody

1. USP24 level was decreased during the early stage of cancer and the mitotic stage of the cell cycle to regulate its substrates p300, Bax, E2F4 and securin, resulting in decreased cell apoptosis and increased cell cycle progression and, thus, cancer formation. PMID: 27991932
2. Data show that ubiquitin-specific peptidase 24 (USP24) is highly expressed in cell lines with enhanced malignancy and in late-stage lung cancer clinical samples. PMID: 26568301
3. USP24 deubiquitinase regulates the DNA damage response by directly targeting the p53 tumor suppressor. PMID: 25578727
4. the novel compound EOAI3402143 dose-dependently inhibited Usp9x and Usp24 activity, increased tumor cell apoptosis, and fully blocked or regressed myeloma tumors in mice. PMID: 25814533
5. These results suggested that USP24 expression is tightly regulated at its transcription level and NFkappaB plays an important role in this process. PMID: 24286619
6. The knockdown of USP24 in two human cell lines decreased the steady-state levels of DDB2, indicating that USP24-mediated DDB2 deubiquitination prevents DDB2 degradation. PMID: 23159851
7. The present study is the first to report a lack of association between SNPs of USP24 and parkinson disease in Han Chinese patients. Other PMID: 22923019
8. USP24 alone plays a role in PD susceptibility among Taiwanese people >or=60 years of age, or acting synergistically with USP40 and UCHL1 in the total subjects. PMID: 20302855
9. Data suggest that genetic variants in USP24 affect the risk for late-onset Parkinson disease (PD), which is consistent with the predicted role of the ubiquitination pathway in PD etiology. PMID: 16917932

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HGNC: 12623

OMIM: 610569

KEGG: hsa:23358

STRING: 9606.ENSP00000294383

UniGene: Hs.477009