USP33 Antibody

Datasheet
Code CSB-PA025724GA01HU
Size US$685
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Product Details

Uniprot No. Q8TEY7
Target Names USP33
Alternative Names Deubiquitinating enzyme 33 antibody; EC 3 1 2 15 antibody; hVDU1 antibody; KIAA1097 antibody; MGC16868 antibody; OTTHUMP00000011234 antibody; OTTHUMP00000011330 antibody; OTTHUMP00000011331 antibody; pVHL interacting deubiquitinating enzyme 1 antibody; Ubiquitin carboxyl terminal hydrolase 33 antibody; Ubiquitin carboxyl-terminal hydrolase 33 antibody; Ubiquitin specific peptidase 33 antibody; Ubiquitin specific processing protease 33 antibody; ubiquitin specific protease 33 antibody; Ubiquitin thioesterase 33 antibody; Ubiquitin thiolesterase 33 antibody; Ubiquitin-specific-processing protease 33 antibody; UBP33_HUMAN antibody; USP 33 antibody; Usp33 antibody; VDU 1 antibody; VDU1 antibody; VHL interacting deubiquitinating enzyme 1 antibody; VHL-interacting deubiquitinating enzyme 1 antibody
Raised in Rabbit
Species Reactivity Human,Mouse,Rat
Immunogen Human USP33
Immunogen Species Homo sapiens (Human)
Isotype IgG
Purification Method Antigen Affinity Purified
Concentration It differs from different batches. Please contact us to confirm it.
Buffer PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
Tested Applications ELISA,WB,IHC
Protocols ELISA Protocol
Western Blotting(WB) Protocol
Immunohistochemistry (IHC) Protocol
Troubleshooting and FAQs Antibody FAQs
Storage Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Target Data

Function Deubiquitinating enzyme involved in various processes such as centrosome duplication, cellular migration and beta-2 adrenergic receptor/ADRB2 recycling. Involved in regulation of centrosome duplication by mediating deubiquitination of CCP110 in S and G2/M phase, leading to stabilize CCP110 during the period which centrioles duplicate and elongate. Involved in cell migration via its interaction with intracellular domain of ROBO1, leading to regulate the Slit signaling. Plays a role in commissural axon guidance cross the ventral midline of the neural tube in a Slit-dependent manner, possibly by mediating the deubiquitination of ROBO1. Acts as a regulator of G-protein coupled receptor (GPCR) signaling by mediating the deubiquitination of beta-arrestins (ARRB1 and ARRB2) and beta-2 adrenergic receptor (ADRB2). Plays a central role in ADRB2 recycling and resensitization after prolonged agonist stimulation by constitutively binding ADRB2, mediating deubiquitination of ADRB2 and inhibiting lysosomal trafficking of ADRB2. Upon dissociation, it is probably transferred to the translocated beta-arrestins, leading to beta-arrestins deubiquitination and disengagement from ADRB2. This suggests the existence of a dynamic exchange between the ADRB2 and beta-arrestins. Deubiquitinates DIO2, thereby regulating thyroid hormone regulation. Mediates deubiquitination of both 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains.
Gene References into Functions
  1. USP33 was downregulated in gastric adenocarcinoma. PMID: 29802710
  2. Fluorescence-activated cell sorting experiment found no significant effect of USP33 on cell cycle, whereas the apoptotic caspase proteins were activated by USP33-overexpression and the interaction between USP33 and Robo1 protein was identified, and knockdown of Robo1 enhancing the oncogenic effect upon USP33-knockdown, suggesting that USP33 may inhibit tumor progression through Robo1 signaling. PMID: 29533940
  3. USP33 may indirectly regulate the degradation and recycling of CXCR4 through deubiquitinating beta-arrestin2, promoting colorectal tumor cell metastasis. PMID: 27835898
  4. the E3 ligase beta-TrCP regulates cellular USP33 levels by the ubiquitin-proteasomal proteolysis. PMID: 28506875
  5. Data show thata combining cyclin-dependent kinase 2 (CDK2) antagonism and ubiquitin thioesterase 33 (USP33) depletion augments anaphase catastrophe via changes in centrosomal protein of 110 kDa (CP110) protein expression. PMID: 26304236
  6. Data show that ubiquitin specific peptidase 33 (USP33) mediates nerve tissue proteins Slit-Robo signaling in lung cancer cell migration. PMID: 24981056
  7. USP33 as a previously unknown tumor-suppressing gene. PMID: 25242263
  8. Knockdown or chemical inhibition of p97 causes robust accumulation of USP33 due to inhibition of its degradation PMID: 24855649
  9. nutrient starvation induces RALB deubiquitylation by accumulation and relocalization of the deubiquitylase USP33 to RALB-positive vesicles PMID: 24056301
  10. using human cells, identification of a new mechanism for the regulation of centrosome duplication that requires USP33, a deubiquitinating enzyme that is able to regulate CP110 levels PMID: 23486064
  11. VDU1 has a role in amplifying the increase in type 2 iodothyronine deiodinase activity that results from catecholamine-stimulated de novo synthesis PMID: 12865408
  12. The solution structure of the ZnF UBP domain of USP33 has been determined. PMID: 17766394
  13. VDU1 was identified as a protein partner of hSP56. PMID: 19118533
  14. USP33 and Mdm2 function reciprocally and favor respectively the stability or lability of the receptor beta-arrestin complex PMID: 19363159
  15. Our results reveal a previously unknown role for USP33 in vertebrate commissural axon guidance and in Slit signaling PMID: 19684588
  16. Data uncover a previously unknown function of USP33 and reveal a new player in Slit-Robo signaling in cancer cell migration. PMID: 19706539

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Subcellular Location Cytoplasm, perinuclear region, Cytoplasm, cytoskeleton, microtubule organizing center, centrosome
Protein Families Peptidase C19 family, USP20/USP33 subfamily
Tissue Specificity Widely expressed.
Database Links

HGNC: 20059

OMIM: 615146

KEGG: hsa:23032

STRING: 9606.ENSP00000350009

UniGene: Hs.480597

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