USP4 Antibody, Biotin conjugated

1. Data showed significantly increased expression of USP4 in cancer tissues compared to that in para-carcinoma tissues. PMID: 28946564
2. The data indicate that USP4 interacts with and deubiquitinates IRF4, and also stabilizes IRF4 protein and promotes IRF4 function to facilitate IL-4 expression in Th2 cells, which may be related to the pathological process of rheumatic heart disease. PMID: 28791349
3. These results identify USP4 as a novel regulator of Dvl in Wnt/beta-catenin signal and show its involvement in Wnt3a-induced osteoblast differentiation PMID: 27128386
4. Data suggest that ubiquitin specific protease 4 (USP4) interacts with interferon regulatory factor 8 (IRF8) and, by its Lys48-specific deubiquitinase/endopeptidase activity, stabilizes IRF8 protein levels in regulatory T-lymphocytes; USP4 and IRF8 are also expressed in helper T-lymphocytes. PMID: 28477415
5. USP4 inhibits p53 and NF-kappaB through deubiquitinating and stabilizing HDAC2 PMID: 26411366
6. ubiquitin-specific protease 4 (USP4) is a binding partner of RNPS1. PMID: 27990632
7. Data indicate that programmed cell death 4 (PDCD4) was identified to be a target of ubiquitin-specific protease 4 (USP4), which plays a role as a tumor suppressor. PMID: 27430936
8. Ubiquitin-specific protease 4 (USP4), recently identified as a beta-catenin-specific deubiquitinylating enzyme, was highly expressed in PC14PE6/LvBr4 cells and involved in the increased stability of beta-catenin protein. PMID: 26883469
9. USP4 knockdown in HCT116, a colon cancer cell line, reduced invasion and migration activity. PMID: 26189775
10. USP4 cooperates with CtIP in DNA double-strand break end resection. PMID: 26387952
11. Results demonstrate that aberrant expression of USP4 contributes to the development and progression of colorectal cancer and reveal a critical mechanism underlying USP4-mediated oncogenic activity. PMID: 26669864
12. findings thus identify USP4 as a novel DNA repair regulator and invoke a model in which ubiquitin adducts regulate USP enzyme interactions and functions. PMID: 26455393
13. USP4 and IL-17 mRNA, but not RORgammat mRNA, were significantly elevated in CD4(+) T cells from patients with rheumatic heart disease PMID: 25821221
14. USP4 overexpression is associated with hepatocellular carcinoma. PMID: 24798342
15. Authors identified USP4 as a new positive regulator for RIG-I that acts through deubiquitinating K48-linked ubiquitin chains and stabilizing RIG-I. PMID: 23388719
16. Data suggest that USP4 down-regulates RIP1 (receptor-interacting serine-threonine kinase 1)-mediated TNFalpha (tumor necrosis factor-alpha) activation and promotes TNFalpha-induced apoptosis via deubiquitination of RIP1 in head/neck carcinoma. PMID: 23313255
17. the interaction with USP4 may regulate the structure and function of the proteasome or the turnover of specific proteasomal substrates. PMID: 23022198
18. USP4 plays an essential role in negative regulation of the TLR/IL-1R signaling-mediated innate immune response PMID: 22262844
19. Results uncover USP4 as an important determinant for crosstalk between TGF-beta/TGF-beta type I receptor and AKT signalling pathways. PMID: 22706160
20. identify the Ubiquitin-Specific Protease 4 (USP4) as an enzyme that removes ubiquitin from PDK1 in vivo and in vitro and co-localizes with PDK1 at the plasma membrane when the two proteins are overexpressed, indicating direct deubiquitination PMID: 22347420
21. Results demonstrate that USP4 serves as a critical control to downregulate TNFalpha-induced NF-kappaB activation through deubiquitinating TAK1. PMID: 21331078
22. USP4 deubiquitinates both TRAF2 and TRAF6 in vivo and in vitro in a deubiquitinase activity-dependent manner and inhibits TNFalpha-induced cancer cell migration. PMID: 22029577
23. Studies indicate that the cylindromatosis/turban tumor syndrome gene (CYLD) ranked highest, followed by acylaminoacyl-peptidase (APEH), dystroglycan (DAG1), macrophage-stimulating protein (MST1) and ubiquitin-specific peptidase 4 (USP4). PMID: 21931648
24. modulation of USP4 expression may provide a new means to interfere with canonical Wnt signalling in a variety of physiological and pathological conditions PMID: 20141612
25. These results suggest that UnpEL colocalizes with the unubiquitinated form of Ro52 to the cytoplasmic rod-like structures. PMID: 16316627
26. Ro52 and UnpEL transregulate each other by ubiquitination and deubiquitination PMID: 16472766

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HGNC: 12627

OMIM: 603486

KEGG: hsa:7375

STRING: 9606.ENSP00000265560

UniGene: Hs.403828