USP49 Antibody

Code CSB-PA025741GA01HU
Size $600
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Product Details

Uniprot No.
Target Names
USP49
Alternative Names
USP49 antibody; Ubiquitin carboxyl-terminal hydrolase 49 antibody; EC 3.4.19.12 antibody; Deubiquitinating enzyme 49 antibody; Ubiquitin thioesterase 49 antibody; Ubiquitin-specific-processing protease 49 antibody
Raised in
Rabbit
Species Reactivity
Human,Mouse,Rat
Immunogen
Human USP49
Immunogen Species
Homo sapiens (Human)
Isotype
IgG
Purification Method
Antigen Affinity purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
Tested Applications
ELISA,WB,IHC
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
Specifically deubiquitinates histone H2B at 'Lys-120' (H2BK120Ub). H2BK120Ub is a specific tag for epigenetic transcriptional activation and acts as a regulator of mRNA splicing. Deubiquitination is required for efficient cotranscriptional splicing of a large set of exons.
Gene References into Functions
  1. Mechanistically, USP49 deubiquitinates and stabilizes FKBP51, which in turn enhances PHLPP's capability to dephosphorylate AKT. PMID: 28363942
  2. identifies USP49 as a histone H2B-specific deubiquitinase and uncovers a critical role for H2B deubiquitination in cotranscriptional pre-mRNA processing events. PMID: 23824326
Subcellular Location
Nucleus.
Protein Families
Peptidase C19 family
Database Links

HGNC: 20078

KEGG: hsa:25862

STRING: 9606.ENSP00000297229

UniGene: Hs.593575

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301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)
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7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA
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