VCPIP1 Antibody

Datasheet

Code	CSB-PA025814GA01HU
Size	$600
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Product Details
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Target Background

Product Details

Uniprot No.

Q96JH7

Target Names

VCPIP1

Alternative Names

Deubiquitinating protein VCIP135 antibody; DUBA3 antibody; KIAA1850 antibody; Valosin containing protein (p97)/p47 complex interacting protein 1 antibody; Valosin containing protein p97/p47 complex interacting protein 1 antibody; Valosin containing protein p97/p47 complex interacting protein p135 antibody; Valosin-containing protein p97/p47 complex-interacting protein 1 antibody; Valosin-containing protein p97/p47 complex-interacting protein p135 antibody; VCIP1_HUMAN antibody; VCIP135 antibody; VCP/p47 complex-interacting 135-kDa protein antibody; Vcpip1 antibody

Raised in

Rabbit

Species Reactivity

Human,Mouse,Rat

Immunogen

Human VCPIP1

Immunogen Species

Homo sapiens (Human)

Isotype

IgG

Purification Method

Antigen Affinity purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.

Tested Applications

ELISA,WB

Protocols

ELISA Protocol
Western Blotting(WB) Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function

Deubiquitinating enzyme involved in DNA repair and reassembly of the Golgi apparatus and the endoplasmic reticulum following mitosis. Necessary for VCP-mediated reassembly of Golgi stacks after mitosis. Plays a role in VCP-mediated formation of transitional endoplasmic reticulum (tER). Mediates dissociation of the ternary complex containing STX5A, NSFL1C and VCP. Also involved in DNA repair following phosphorylation by ATM or ATR: acts by catalyzing deubiquitination of SPRTN, thereby promoting SPRTN recruitment to chromatin and subsequent proteolytic cleavage of covalent DNA-protein cross-links (DPCs). Hydrolyzes 'Lys-11'- and 'Lys-48'-linked polyubiquitin chains.; (Microbial infection) Regulates the duration of C.botulinum neurotoxin type A (BoNT/A) intoxication by catalyzing deubiquitination of Botulinum neurotoxin A light chain (LC), thereby preventing LC degradation by the proteasome, and accelerating botulinum neurotoxin intoxication in patients.

Gene References into Functions

BoNT/A catalytic light chain binds to, and is a substrate for, the ubiquitin ligase HECTD2. However, the light chain evades proteasomal degradation by the dominant effect of a deubiquitinating enzyme, VCIP135/VCPIP1. This deubiquitinating enzyme binds BoNT/A light chain directly. PMID: 28584101
Phosphorylation and ubiquitination are coordinated via VCIP135 to control Golgi membrane dynamics in the cell cycle. PMID: 25904330
VCIP135 phosphorylation regulates its Golgi membrane association and p97 interaction, and thus contributes to the tight control of the Golgi disassembly and reassembly process during the cell cycle. PMID: 24163436
the phosphorylation of VCIP135 on Threonine-760 and Serine-767 inhibits p97-mediated Golgi membrane fusion at mitosis PMID: 23500464
evidence of tyrosine phosphorylation during sperm capacitation PMID: 12509440

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Subcellular Location

Nucleus. Cytoplasm. Endoplasmic reticulum. Golgi apparatus, Golgi stack.

Database Links

HGNC: 30897

OMIM: 611745

KEGG: hsa:80124

STRING: 9606.ENSP00000309031

UniGene: Hs.632066

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Antibody FAQs What Is an Antibody? How to Choose an Antibody for Scientific Research? The difference between primary antibody and secondary antibod The Meaning of Irregular Antibody Screening Tag Antibodies, Your Good Partner in Protein Research How to Choose the Loading Control Antibodies?

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301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)

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Address

7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA

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