VKORC1L1 Antibody, Biotin conjugated

Code CSB-PA818673LD01HU
Size US$166
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Product Details

Full Product Name
Rabbit anti-Homo sapiens (Human) VKORC1L1 Polyclonal antibody
Uniprot No.
Target Names
VKORC1L1
Alternative Names
VKORC1L1; Vitamin K epoxide reductase complex subunit 1-like protein 1; VKORC1-like protein 1
Raised in
Rabbit
Species Reactivity
Human
Immunogen
Recombinant Human Vitamin K epoxide reductase complex subunit 1-like protein 1 protein (38-91AA)
Immunogen Species
Homo sapiens (Human)
Conjugate
Biotin
Clonality
Polyclonal
Isotype
IgG
Purification Method
>95%, Protein G purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
Form
Liquid
Tested Applications
ELISA
Protocols
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
Involved in vitamin K metabolism. Can reduce inactive vitamin K 2,3-epoxide to active vitamin K (in vitro), and may contribute to vitamin K-mediated protection against oxidative stress. Plays a role in vitamin K-dependent gamma-carboxylation of Glu residues in target proteins.
Gene References into Functions
  1. This study showed that polymorphisms of EPHX1 and VKORC1L1 could be determinants of stable warfarin doses. PMID: 29054760
  2. a concerted action of the four conserved cysteines of VKORC1L1 for active site regeneration PMID: 24532791
  3. VKORC1L1 is responsible for driving vitamin K-mediated intracellular antioxidation pathways critical to cell survival. PMID: 21367861
  4. VKORC1L1 does not affect the variability of warfarin dose requirement in a Japanese patient population PMID: 17996924
Subcellular Location
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Protein Families
VKOR family
Database Links

HGNC: 21492

OMIM: 608838

KEGG: hsa:154807

STRING: 9606.ENSP00000353998

UniGene: Hs.427232

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