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VKORC1L1 Antibody, HRP conjugated

Datasheet
Code CSB-PA818673LB01HU
Size US$166
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Product Details

Full Product Name
Rabbit anti-Homo sapiens (Human) VKORC1L1 Polyclonal antibody
Uniprot No.
Q8N0U8
Target Names
VKORC1L1
Alternative Names
VKORC1L1; Vitamin K epoxide reductase complex subunit 1-like protein 1; VKORC1-like protein 1
Raised in
Rabbit
Species Reactivity
Human
Immunogen
Recombinant Human Vitamin K epoxide reductase complex subunit 1-like protein 1 protein (38-91AA)
Immunogen Species
Homo sapiens (Human)
Conjugate
HRP
Clonality
Polyclonal
Isotype
IgG
Purification Method
>95%, Protein G purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
Form
Liquid
Tested Applications
ELISA
Protocols
ELISA Protocol
Troubleshooting and FAQs
Antibody FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Usage
For Research Use Only. Not for use in diagnostic or therapeutic procedures.

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VKORC1L1 Antibodies

VKORC1L1 Proteins

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Target Background

Function
Involved in vitamin K metabolism. Can reduce inactive vitamin K 2,3-epoxide to active vitamin K (in vitro), and may contribute to vitamin K-mediated protection against oxidative stress. Plays a role in vitamin K-dependent gamma-carboxylation of Glu residues in target proteins.
Gene References into Functions
  1. This study showed that polymorphisms of EPHX1 and VKORC1L1 could be determinants of stable warfarin doses. PMID: 29054760
  2. a concerted action of the four conserved cysteines of VKORC1L1 for active site regeneration PMID: 24532791
  3. VKORC1L1 is responsible for driving vitamin K-mediated intracellular antioxidation pathways critical to cell survival. PMID: 21367861
  4. VKORC1L1 does not affect the variability of warfarin dose requirement in a Japanese patient population PMID: 17996924
Subcellular Location
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Protein Families
VKOR family
Database Links

HGNC: 21492

OMIM: 608838

KEGG: hsa:154807

STRING: 9606.ENSP00000353998

UniGene: Hs.427232

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