VP2 Antibody, HRP conjugated

Code CSB-PA302471LB01CID
Size US$166
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Product Details

Full Product Name
Rabbit anti-Chicken anemia virus (isolate Germany Cuxhaven-1) (CAV) VP2 Polyclonal antibody
Uniprot No.
Target Names
VP2
Alternative Names
VP2Dual specificity protein phosphatase VP2 antibody; EC 3.1.3.16 antibody; EC 3.1.3.48 antibody
Raised in
Rabbit
Species Reactivity
Chicken anemia virus
Immunogen
Recombinant Chicken anemia virus Dual specificity protein phosphatase VP2 protein (1-216AA)
Immunogen Species
Chicken anemia virus (isolate Germany Cuxhaven-1) (CAV)
Conjugate
HRP
Clonality
Polyclonal
Isotype
IgG
Purification Method
>95%, Protein G purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Form
Liquid
Tested Applications
ELISA
Protocols
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
May act as a scaffold protein in virion assembly. May also play a role in intracellular signaling during viral replication.
Gene References into Functions
  1. The deletion of the C-terminal region of apoptin also impaired the replication of chicken anemia virus and attenuated its virulence in chickens. PMID: 28222746
  2. this study reports the use of apoptin and poly (I:C) combination as a novel strategy for cancer immunotherapy PMID: 27064544
  3. VP3-induced apoptosis, caspase-dependent intrinsic pathway plays an important role with the cleavage of poly (ADP-ribose) polymerase (PARP) PMID: 25809990
  4. Results show that The apoptosis induced by human adenovirus serotype 5 (AdHu5)-apoptin was independent of anti-apoptotic Bcl-2 and Bcl-xL proteins and the p53 pathway. PMID: 23812727
  5. In silico three-dimensional modeling of apoptin, molecular docking experiments between apoptin model and the known structure of Bcr-Abl, and the 3D structures of SH2 domains of CrkL and Bcr-Abl, were performed. PMID: 22253690
  6. These data demonstrate that Hsc70 is responsible for the down-regulation of Apoptin induced RelA/p65 gene expression. PMID: 21707973
  7. Apoptin induced the translocation of endogenous Hsc70 from the cytoplasm to the nucleus, and both were co-localized in the nucleus. PMID: 21565169
  8. Apoptin, expressed from the pseudotype baculovirus vector, has the potential to become a therapeutic agent for the treatment of solid tumors PMID: 19824041
  9. Apoptin, a protein from chicken anemia virus without an apparent cellular homologue, can induce apoptosis in mammalian cells. Its cytotoxicity is limited to transformed or tumor cells. PMID: 14765135
  10. Apoptin induces chromatin condensation when it is expressed in the nucleus and in the cytoplasm. PMID: 15965608
  11. role of c-Jun N-terminal kinase (JNK) in the apoptosis induced by apoptin gene in human lymphoma cell U937 PMID: 15989809
  12. Apoptin expression caused an increase in the tumor suppressor lipid ceramide, which regulates the cellular stress response PMID: 16887394
  13. apoptin kills tumor cells independently of PML and sumoylation, however, the interaction of apoptin with PML and small ubiquitin-like modifier (SUMO) proteins might be relevant for chicken anemia virus replication PMID: 16924230
  14. suggest that apoptin modulates ceramide/sphingolipid metabolism as part of its mechanism of action PMID: 16926120
  15. apoptin had an anti-neoplastic effect in vivo and in vitro in RSV-induced tumours PMID: 16963752
  16. T108 phosphorylation may only be required for the apoptotic activity mediated through the C-terminal apoptosis domain. PMID: 17223075
  17. PI3-K/Akt pathways have a dual role in both survival and cell death processes depending on the stimulus. PMID: 18021174
  18. Human peptidyl-prolyl isomerase-like 3 (Ppil3) is one of the Apoptin-associated proteins. PMID: 18474220
  19. C-terminus of apoptin (residues 74-121) is sufficient for tumor cell-enhanced nuclear targeting through phosphoinhibition of apoptin (74-121)-mediated nuclear export occurring exclusively in tumor cells. PMID: 18798550
  20. apoptin is necessary not only for DNA replication but also virus-like particle production of chicken anemia virus PMID: 19091368
  21. the pathway of apoptin-induced apoptosis and show that it essentially depends on abnormal phosphatidylinositol 3-kinase (PI3-kinase)/Akt activation, resulting in the activation of the cyclin-dependent kinase CDK2 PMID: 19103742
  22. Apoptin specifically kills tumor cells while leaving normal cells unharmed. The subcellular localization of apoptin appears to be crucial for this tumor-selective activity. Review. PMID: 19374922

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Protein Families
Gyrovirus protein VP2 family
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