Recombinant Chicken anemia virus Dual specificity protein phosphatase VP2 (VP2)

1. The deletion of the C-terminal region of apoptin also impaired the replication of chicken anemia virus and attenuated its virulence in chickens. PMID: 28222746
2. this study reports the use of apoptin and poly (I:C) combination as a novel strategy for cancer immunotherapy PMID: 27064544
3. VP3-induced apoptosis, caspase-dependent intrinsic pathway plays an important role with the cleavage of poly (ADP-ribose) polymerase (PARP) PMID: 25809990
4. Results show that The apoptosis induced by human adenovirus serotype 5 (AdHu5)-apoptin was independent of anti-apoptotic Bcl-2 and Bcl-xL proteins and the p53 pathway. PMID: 23812727
5. In silico three-dimensional modeling of apoptin, molecular docking experiments between apoptin model and the known structure of Bcr-Abl, and the 3D structures of SH2 domains of CrkL and Bcr-Abl, were performed. PMID: 22253690
6. These data demonstrate that Hsc70 is responsible for the down-regulation of Apoptin induced RelA/p65 gene expression. PMID: 21707973
7. Apoptin induced the translocation of endogenous Hsc70 from the cytoplasm to the nucleus, and both were co-localized in the nucleus. PMID: 21565169
8. Apoptin, expressed from the pseudotype baculovirus vector, has the potential to become a therapeutic agent for the treatment of solid tumors PMID: 19824041
9. Apoptin, a protein from chicken anemia virus without an apparent cellular homologue, can induce apoptosis in mammalian cells. Its cytotoxicity is limited to transformed or tumor cells. PMID: 14765135
10. Apoptin induces chromatin condensation when it is expressed in the nucleus and in the cytoplasm. PMID: 15965608
11. role of c-Jun N-terminal kinase (JNK) in the apoptosis induced by apoptin gene in human lymphoma cell U937 PMID: 15989809
12. Apoptin expression caused an increase in the tumor suppressor lipid ceramide, which regulates the cellular stress response PMID: 16887394
13. apoptin kills tumor cells independently of PML and sumoylation, however, the interaction of apoptin with PML and small ubiquitin-like modifier (SUMO) proteins might be relevant for chicken anemia virus replication PMID: 16924230
14. suggest that apoptin modulates ceramide/sphingolipid metabolism as part of its mechanism of action PMID: 16926120
15. apoptin had an anti-neoplastic effect in vivo and in vitro in RSV-induced tumours PMID: 16963752
16. T108 phosphorylation may only be required for the apoptotic activity mediated through the C-terminal apoptosis domain. PMID: 17223075
17. PI3-K/Akt pathways have a dual role in both survival and cell death processes depending on the stimulus. PMID: 18021174
18. Human peptidyl-prolyl isomerase-like 3 (Ppil3) is one of the Apoptin-associated proteins. PMID: 18474220
19. C-terminus of apoptin (residues 74-121) is sufficient for tumor cell-enhanced nuclear targeting through phosphoinhibition of apoptin (74-121)-mediated nuclear export occurring exclusively in tumor cells. PMID: 18798550
20. apoptin is necessary not only for DNA replication but also virus-like particle production of chicken anemia virus PMID: 19091368
21. the pathway of apoptin-induced apoptosis and show that it essentially depends on abnormal phosphatidylinositol 3-kinase (PI3-kinase)/Akt activation, resulting in the activation of the cyclin-dependent kinase CDK2 PMID: 19103742
22. Apoptin specifically kills tumor cells while leaving normal cells unharmed. The subcellular localization of apoptin appears to be crucial for this tumor-selective activity. Review. PMID: 19374922

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