VPS45 Antibody

Datasheet

Code	CSB-PA025912GA01HU
Size	$600
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Product Details
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Customer Reviews and Q&A
Target Background

Product Details

Uniprot No.

Q9NRW7

Target Names

VPS45

Alternative Names

h-VPS45 antibody; H1 antibody; H1VPS45 antibody; HGNC:14579 antibody; hlVps45 antibody; Leucocyte vacuolar protein sorting 45 antibody; OTTHUMP00000014482 antibody; Vacuolar protein sorting 45 homolog (S. cerevisiae) antibody; Vacuolar protein sorting 45A (yeast homolog) antibody; Vacuolar protein sorting 45A antibody; Vacuolar protein sorting 45B (yeast) antibody; Vacuolar protein sorting-associated protein 45 antibody; Vps45 antibody; VPS45_HUMAN antibody; VPS45A antibody; VPS45B antibody; VPS54A antibody; VSP45 antibody; VSP45A antibody

Raised in

Rabbit

Species Reactivity

Human,Mouse,Rat

Immunogen

Human VPS45

Immunogen Species

Homo sapiens (Human)

Isotype

IgG

Purification Method

Antigen Affinity Purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.

Tested Applications

ELISA,WB

Protocols

ELISA Protocol
Western Blotting(WB) Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Customer Reviews and Q&A

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Target Background

Function

May play a role in vesicle-mediated protein trafficking from the Golgi stack through the trans-Golgi network.

Gene References into Functions

A homozygous VPS45 p.E238K mutation is associated with severe congenital neutropenia with neurological impairment. PMID: 26358756
we identified a Thr224Asn mutation in the VPS45 gene in infants from consanguineous families who suffered from life-threatening neutropenia. PMID: 23599270
Defective endosomal intracellular protein trafficking due to biallelic mutations in VPS45 underlies a new immunodeficiency syndrome involving impaired neutrophil function. PMID: 23738510
Data implicate hVps45 and Rabenosyn-5 in post early endosome transport, and suggest that their interaction serves as a nexus to promote bidirectional transport along the endosome-to-recycling compartment and endosome-to-Golgi axes. PMID: 19931244

Involvement in disease

Neutropenia, severe congenital 5, autosomal recessive (SCN5)

Subcellular Location

Golgi apparatus membrane; Peripheral membrane protein. Endosome membrane; Peripheral membrane protein.

Protein Families

STXBP/unc-18/SEC1 family

Tissue Specificity

Ubiquitous. Expression was highest in testis, heart and brain, intermediate in kidney, spleen, prostate, ovary, small intestine and thymus and low in lung, skeletal muscle, placenta, colon, pancreas, peripheral blood leukocytes and liver.

Database Links

HGNC: 14579

OMIM: 610035

KEGG: hsa:11311

STRING: 9606.ENSP00000358126

UniGene: Hs.443750

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Antibody FAQs What Is an Antibody? How to Choose an Antibody for Scientific Research? The difference between primary antibody and secondary antibod The Meaning of Irregular Antibody Screening Tag Antibodies, Your Good Partner in Protein Research How to Choose the Loading Control Antibodies?

Related pathways

Endocytosis

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301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)

[email protected]

Address

7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA

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