VTA1 Antibody

Datasheet

Code	CSB-PA882062LA01HU
Size	US$166
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Image	Immunohistochemistry of paraffin-embedded human gastric cancer using CSB-PA882062LA01HU at dilution of 1:100 Immunohistochemistry of paraffin-embedded human ovarian cancer using CSB-PA882062LA01HU at dilution of 1:100
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Product Details
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Target Background

Product Details

Full Product Name

Rabbit anti-Homo sapiens (Human) VTA1 Polyclonal antibody

Uniprot No.

Q9NP79

Target Names

VTA1

Alternative Names

C6orf55 antibody; Chromosome 6 open reading frame 55 antibody; Dopamine responsive protein DRG 1 antibody; Dopamine-responsive gene 1 protein antibody; DRG 1 antibody; DRG-1 antibody; DRG1 antibody; Homolog of mouse SKD1 binding protein 1 antibody; HSPC228 antibody; LIP5 antibody; LYST interacting protein 5 antibody; LYST-interacting protein 5 antibody; My012 antibody; SBP1 antibody; SKD1 binding protein 1 antibody; SKD1-binding protein 1 antibody; Vacuolar protein sorting-associated protein VTA1 homolog antibody; Vps20 associated 1 homolog (S. cerevisiae) antibody; VTA1 antibody; VTA1_HUMAN antibody

Raised in

Rabbit

Species Reactivity

Human

Immunogen

Recombinant Human Vacuolar protein sorting-associated protein VTA1 homolog protein (23-307AA)

Immunogen Species

Homo sapiens (Human)

Conjugate

Non-conjugated

The VTA1 Antibody (Product code: CSB-PA882062LA01HU) is Non-conjugated. For VTA1 Antibody with conjugates, please check the following table.

Conjugate	Product Code	Product Name	Application
HRP	CSB-PA882062LB01HU	VTA1 Antibody, HRP conjugated	ELISA
FITC	CSB-PA882062LC01HU	VTA1 Antibody, FITC conjugated
Biotin	CSB-PA882062LD01HU	VTA1 Antibody, Biotin conjugated	ELISA

Clonality

Polyclonal

Isotype

IgG

Purification Method

>95%, Protein G purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4

Form

Liquid

Tested Applications

ELISA, IHC

Recommended Dilution

Application	Recommended Dilution
IHC	1:20-1:200

Protocols

ELISA Protocol
Immunohistochemistry (IHC) Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Usage

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

Customer Reviews and Q&A

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Target Background

Function

Involved in the endosomal multivesicular bodies (MVB) pathway. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids. Thought to be a cofactor of VPS4A/B, which catalyzes disassembles membrane-associated ESCRT-III assemblies. Involved in the sorting and down-regulation of EGFR. Involved in HIV-1 budding.

Gene References into Functions

Data suggest that AQP2 binds LIP5 in a AQP2-phosphorylation-dependent manner; phospho-mimicking mutations and phosphorylation reduce thermal stability of AQP2; AQP2 phosphorylation allosterically controls its interaction with LIP5. [AQP2 = aquaporin 2; LIP5 = LYST-interacting protein 5; LYST = lysosomal trafficking regulator protein] PMID: 28710278
Crystal structures of three molecular complexes reveal that IST1 binds to the MIT domains of VPS4 and LIP5. PMID: 25657007
the tandem MIT domain of LIP5 binds different types of ESCRT-III proteins, promoting assembly of active VPS4 enzymes on the polymeric ESCRT-III substrate. PMID: 23105106
LIP5 protein expression in a mouse tissue panel and various rodent and human tissues were studied. PMID: 20358264

Subcellular Location

Cytoplasm. Endosome membrane; Peripheral membrane protein.

Protein Families

VTA1 family

Database Links

HGNC: 20954

OMIM: 610902

KEGG: hsa:51534

STRING: 9606.ENSP00000356602

UniGene: Hs.431367

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Protein Service

Gene Synthesis Service

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Antibody FAQs What Is an Antibody? How to Choose an Antibody for Scientific Research? The difference between primary antibody and secondary antibod The Meaning of Irregular Antibody Screening Tag Antibodies, Your Good Partner in Protein Research How to Choose the Loading Control Antibodies?

Related pathways

Endocytosis

Call us

301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)

[email protected]

Address

7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA

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