VTA1 Antibody

Datasheet

Code	CSB-PA025940GA01HU
Size	$600
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Product Details
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Customer Reviews and Q&A
Target Background

Product Details

Uniprot No.

Q9NP79

Target Names

VTA1

Alternative Names

C6orf55 antibody; Chromosome 6 open reading frame 55 antibody; Dopamine responsive protein DRG 1 antibody; Dopamine-responsive gene 1 protein antibody; DRG 1 antibody; DRG-1 antibody; DRG1 antibody; Homolog of mouse SKD1 binding protein 1 antibody; HSPC228 antibody; LIP5 antibody; LYST interacting protein 5 antibody; LYST-interacting protein 5 antibody; My012 antibody; SBP1 antibody; SKD1 binding protein 1 antibody; SKD1-binding protein 1 antibody; Vacuolar protein sorting-associated protein VTA1 homolog antibody; Vps20 associated 1 homolog (S. cerevisiae) antibody; VTA1 antibody; VTA1_HUMAN antibody

Raised in

Rabbit

Species Reactivity

Human,Mouse,Rat

Immunogen

Human VTA1

Immunogen Species

Homo sapiens (Human)

Isotype

IgG

Purification Method

Antigen Affinity purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.

Tested Applications

ELISA,WB,IF

Protocols

ELISA Protocol
Western Blotting(WB) Protocol
Immunofluorescence (IF) Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Customer Reviews and Q&A

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Target Background

Function

Involved in the endosomal multivesicular bodies (MVB) pathway. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids. Thought to be a cofactor of VPS4A/B, which catalyzes disassembles membrane-associated ESCRT-III assemblies. Involved in the sorting and down-regulation of EGFR. Involved in HIV-1 budding.

Gene References into Functions

Data suggest that AQP2 binds LIP5 in a AQP2-phosphorylation-dependent manner; phospho-mimicking mutations and phosphorylation reduce thermal stability of AQP2; AQP2 phosphorylation allosterically controls its interaction with LIP5. [AQP2 = aquaporin 2; LIP5 = LYST-interacting protein 5; LYST = lysosomal trafficking regulator protein] PMID: 28710278
Crystal structures of three molecular complexes reveal that IST1 binds to the MIT domains of VPS4 and LIP5. PMID: 25657007
the tandem MIT domain of LIP5 binds different types of ESCRT-III proteins, promoting assembly of active VPS4 enzymes on the polymeric ESCRT-III substrate. PMID: 23105106
LIP5 protein expression in a mouse tissue panel and various rodent and human tissues were studied. PMID: 20358264

Subcellular Location

Cytoplasm. Endosome membrane; Peripheral membrane protein.

Protein Families

VTA1 family

Database Links

HGNC: 20954

OMIM: 610902

KEGG: hsa:51534

STRING: 9606.ENSP00000356602

UniGene: Hs.431367

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Protein Service

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Antibody FAQs What Is an Antibody? How to Choose an Antibody for Scientific Research? The difference between primary antibody and secondary antibod The Meaning of Irregular Antibody Screening Tag Antibodies, Your Good Partner in Protein Research How to Choose the Loading Control Antibodies?

Related pathways

Endocytosis

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301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)

[email protected]

Address

7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA

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