WAC Antibody

Code CSB-PA861133HA01HU
Size US$166
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  • Immunohistochemistry of paraffin-embedded human brain tissue using CSB-PA861133HA01HU at dilution of 1:100

  • Immunohistochemistry of paraffin-embedded human liver cancer using CSB-PA861133HA01HU at dilution of 1:100

  • Immunofluorescent analysis of MCF-7 cells using CSB-PA861133HA01HU at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)

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Product Details

Full Product Name
Rabbit anti-Homo sapiens (Human) WAC Polyclonal antibody
Uniprot No.
Target Names
WAC
Alternative Names
1110067P07Rik antibody; BA48B24 antibody; BA48B24.1 antibody; BM 016 antibody; FLJ31290 antibody; KIAA1844 antibody; MGC10753 antibody; OTTHUMP00000019380 antibody; OTTHUMP00000019382 antibody; PRO1741 antibody; wac antibody; WAC_HUMAN antibody; WW domain containing adapter protein with coiled coil antibody; WW domain containing adaptor with coiled coil antibody; WW domain-containing adapter protein with coiled-coil antibody; Wwp4 antibody
Raised in
Rabbit
Species Reactivity
Human
Immunogen
Recombinant Human WW domain-containing adapter protein with coiled-coil protein (10-102AA)
Immunogen Species
Homo sapiens (Human)
Conjugate
Non-conjugated

The WAC Antibody (Product code: CSB-PA861133HA01HU) is Non-conjugated. For WAC Antibody with conjugates, please check the following table.

Available Conjugates
Conjugate Product Code Product Name Application
HRP CSB-PA861133HB01HU WAC Antibody, HRP conjugated ELISA
FITC CSB-PA861133HC01HU WAC Antibody, FITC conjugated
Biotin CSB-PA861133HD01HU WAC Antibody, Biotin conjugated ELISA
Clonality
Polyclonal
Isotype
IgG
Purification Method
>95%, Protein G purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
Form
Liquid
Tested Applications
ELISA, IHC, IF
Recommended Dilution
Application Recommended Dilution
IHC 1:20-1:200
IF 1:50-1:200
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Customer Reviews and Q&A

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Target Background

Function
Acts as a linker between gene transcription and histone H2B monoubiquitination at 'Lys-120' (H2BK120ub1). Interacts with the RNA polymerase II transcriptional machinery via its WW domain and with RNF20-RNF40 via its coiled coil region, thereby linking and regulating H2BK120ub1 and gene transcription. Regulates the cell-cycle checkpoint activation in response to DNA damage. Positive regulator of amino acid starvation-induced autophagy. Also acts as a negative regulator of basal autophagy. Positively regulates MTOR activity by promoting, in an energy-dependent manner, the assembly of the TTT complex composed of TELO2, TTI1 and TTI2 and the RUVBL complex composed of RUVBL1 and RUVBL2 into the TTT-RUVBL complex. This leads to the dimerization of the mTORC1 complex and its subsequent activation. May negatively regulate the ubiquitin proteasome pathway.
Gene References into Functions
  1. Our observation allows us to redefine the smallest region of overlap among patients reported so far, with a size of 80 Kb and which contains only the WAC gene. These findings strengthen the hypothesis that haploinsufficency of WAC gene might be likely responsible for intellectual disability and behavior disorders. PMID: 27119754
  2. De novo WAC loss-of-function mutations were identified through exome sequencing of individuals with unexplained intellectual disability. PMID: 26757981
  3. WAC loss-of-function mutations cause a recognisable syndrome characterised by dysmorphic features, developmental delay and hypotonia and recapitulate 10p11.23 microdeletion syndrome PMID: 26264232
  4. The identification of SCOC and WAC as novel regulatory proteins with diverse functions in autophagy contributes towards a fuller understanding of autophagosome formation. PMID: 22354037
Involvement in disease
DeSanto-Shinawi syndrome (DESSH)
Subcellular Location
Nucleus speckle. Nucleus.
Database Links

HGNC: 17327

OMIM: 615049

KEGG: hsa:51322

STRING: 9606.ENSP00000346986

UniGene: Hs.743224

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