WDFY2 Antibody, FITC conjugated

Code CSB-PA850405LC01HU
Size US$166
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Product Details

Full Product Name
Rabbit anti-Homo sapiens (Human) WDFY2 Polyclonal antibody
Uniprot No.
Target Names
WDFY2
Alternative Names
PROF antibody; Propeller-FYVE protein antibody; RP11 147H23.1 antibody; WD repeat and FYVE domain containing 2 antibody; WD repeat and FYVE domain-containing protein 2 antibody; WD40 and FYVE domain containing 2 antibody; WD40- and FYVE domain-containing protein 2 antibody; WDF2 antibody; Wdfy2 antibody; WDFY2_HUMAN antibody; ZFYVE22 antibody; Zinc finger FYVE domain-containing protein 22 antibody
Raised in
Rabbit
Species Reactivity
Human
Immunogen
Recombinant Human WD repeat and FYVE domain-containing protein 2 protein (2-114AA)
Immunogen Species
Homo sapiens (Human)
Conjugate
FITC
Clonality
Polyclonal
Isotype
IgG
Purification Method
>95%, Protein G purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Form
Liquid
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
Acts in an adapter protein-like fashion to mediate the interaction between the kinase PRKCZ and its substrate VAMP2 and increases the PRKCZ-dependent phosphorylation of VAMP2. Positively regulates adipocyte differentiation, by facilitating the phosphorylation and thus inactivation of the anti-adipogenetic transcription factor FOXO1 by the kinase AKT1. Plays a role in endosomal control of AKT2 signaling; required for insulin-stimulated AKT2 phosphorylation and glucose uptake and insulin-stimulated phosphorylation of AKT2 substrates. Participates in transferrin receptor endocytosis.
Gene References into Functions
  1. Our results showed that WDFY2 inhibited cancer cell colony formation and migration via suppressing Akt pathway, making it a potential new therapeutic target in prostate cancer. PMID: 28653900
  2. CDKN2D-WDFY2 fusion could be an important molecular signature for understanding and classifying sub-lineages among heterogeneous high-grade serous ovarian carcinomas. PMID: 24675677
  3. The ProF protein partially co-localizes with EEA1 on vesicular structures and binds to the protein kinases Akt and PKCzeta/lambda (protein kinase Czeta/lambda) via its WD-repeat propeller. PMID: 16792529
  4. WDFY2, the WD40 and FYVE domain containing protein 2, has roles in endocytosis PMID: 16873553
  5. presence of ProF increases the PKCzeta-dependent phosphorylation of VAMP2 in vitro PMID: 17313651

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Subcellular Location
Endosome. Early endosome. Cytoplasm.
Database Links

HGNC: 20482

OMIM: 610418

KEGG: hsa:115825

STRING: 9606.ENSP00000298125

UniGene: Hs.208550

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