WDR73 Antibody, FITC conjugated

Code CSB-PA744047LC01HU
Size US$166
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Product Details

Full Product Name
Rabbit anti-Homo sapiens (Human) WDR73 Polyclonal antibody
Uniprot No.
Target Names
WDR73
Alternative Names
WDR73 antibody; HSPC264WD repeat-containing protein 73 antibody
Raised in
Rabbit
Species Reactivity
Human
Immunogen
Recombinant Human WD repeat-containing protein 73 protein (163-366AA)
Immunogen Species
Homo sapiens (Human)
Conjugate
FITC
Clonality
Polyclonal
Isotype
IgG
Purification Method
Antigen Affinity Purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Form
Liquid
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
May play a role in the regulation of microtubule organization and dynamics.
Gene References into Functions
  1. We expanded the clinical phenotype of GMS with WDR73 gene defect to include retinal dysfunction with missense mutation and developmental dysplasia of the hip. PMID: 29929488
  2. WDR73 as a candidate gene of severe intellectual disability and cerebellar hypoplasia. PMID: 27983999
  3. We document postnatal onset of CA, a retinopathy, basal ganglia degeneration, and short stature as novel features of WDR73-related disease, and define WDR73-related disease as a new entity of infantile neurodegeneration. PMID: 26123727
  4. Nonsense mutation in the WDR73 gene is associated with Galloway-Mowat syndrome PMID: 25873735
  5. WDR73 interacts with mitotic microtubules to regulate cell cycle progression, proliferation and survival in brain PMID: 26070982
  6. WDR73 plays a crucial role in the maintenance of cell architecture and cell survival. PMID: 25466283

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Involvement in disease
Galloway-Mowat syndrome 1 (GAMOS1)
Subcellular Location
Cytoplasm, cytosol. Cytoplasm, cytoskeleton, spindle. Cytoplasm, cytoskeleton, spindle pole. Cleavage furrow.
Protein Families
WD repeat WDR73 family
Tissue Specificity
Expressed in kidney and brain. In the kidney, expressed in glomeruli, most probably in podocytes, and in tubules (at protein level). In the brain, expressed in the cerebellum, with high levels in Purkinje cells and their projecting axons, in the deep cere
Database Links

HGNC: 25928

OMIM: 251300

KEGG: hsa:84942

STRING: 9606.ENSP00000387982

UniGene: Hs.745027

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