ZHX2 Antibody

1. These studies reveal ZHX2 as a potential therapeutic target for clear cell renal cell carcinoma. PMID: 30026228
2. ZHX2 expression in renal cell carcinoma PMID: 28152006
3. Zhx2 is a novel regulator of Mup expression; Zhx2 activates as well as represses expression of target genes PMID: 28258223
4. These results indicated that ZHX2 plays a critical role in the proliferation and osteo/odontogenic differentiation of SCAPs. PMID: 26679602
5. Data show that Zinc-fingers and homeoboxes 2 (ZHX2) represses nuclear transcription factor Y alpha (NF-Y)-mediated activation of multidrug resistance 1 (MDR1) transcription. PMID: 25473899
6. Data indicate that zinc-fingers and homeoboxes 2 (ZHX2) suppresses glypican 3 (GPC3) transcription by binding with its core promoter. PMID: 25195714
7. Two novel markers, rs7840785 (PINX1) and rs7844465 (ZHX2), are significantly associated with carotid intima-media thickness. PMID: 25746325
8. simultaneous application of ZFN and rescue DNA induced gene repair of the disease-causing mutation on the genomic level, resulting in recovery of protein expression. PMID: 22661463
9. Expression of a constitutively active Raf transgene enhances lymphoproliferation, indicating a role for the Ras-MAPK pathway in linker for activation of T cells (LAT)-mediated autoimmune hyperproliferation. PMID: 22984075
10. There was no significant difference in high and low percentage of HbF in GG, GA, and AA bearing individuals showing that ZHX2 gene variant has no role in ameliorating the severity of beta-thalassemia major in the South Indian population from Andhra Pradesh. PMID: 21443521
11. results demonstrate multiple mechanisms decreasing expression of tumor suppressor gene ZHX2 in Hodgkin lymphoma cell lines PMID: 22078940
12. Expression profiling of L-1236 cells following siRNA-mediated knockdown of ZHX2 showed inhibition of genes regulating differentiation and apoptosis, suggesting tumor suppressor activity of ZHX2. PMID: 21987443
13. identification as a transcriptional repressor PMID: 12741956
14. ZHX2, a transcriptional repressor, may participate in globin gene regulation. PMID: 16952470
15. High ZHX2 is associated with metastasis in hepatocellular carcinoma. PMID: 17447851
16. These data support the idea that ZHX2 contributes to AFP repression in the liver after birth and may also be involved in AFP reactivation in liver cancer. PMID: 18194454

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HGNC: 18513

OMIM: 609185

KEGG: hsa:22882

STRING: 9606.ENSP00000314709

UniGene: Hs.377090