ZKSCAN3 Antibody

Datasheet

Code	CSB-PA026494GA01HU
Size	$600
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Product Details
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Target Background

Product Details

Uniprot No.

Q9BRR0

Target Names

ZKSCAN3

Alternative Names

dJ874C20.1 antibody; mszf35 antibody; SCAN-KRAB-zinc finger protein antibody; Skz1 antibody; Zf47 antibody; Zfp-47 antibody; ZFP306 antibody; Zfp307 antibody; Zfp47 antibody; Zinc finger and SCAN domain containing protein 13 antibody; Zinc finger and SCAN domain-containing protein 13 antibody; Zinc finger protein 306 antibody; Zinc finger protein 306; isoform CRA_a antibody; Zinc finger protein 307 antibody; Zinc finger protein 309 antibody; Zinc finger protein 47 homolog antibody; Zinc finger protein with KRAB and SCAN domains 3 antibody; Zinc finger protein with KRAB and SCAN domains 3 antibody; Zinc finger protein zfp47 antibody; Zinc finger with KRAB and SCAN domains 3 antibody; ZKSC3_HUMAN antibody; ZKSCAN3 antibody; ZNF309 antibody; ZSCAN13 antibody; ZSCAN35 antibody

Raised in

Rabbit

Species Reactivity

Human,Mouse

Immunogen

Human ZKSCAN3

Immunogen Species

Homo sapiens (Human)

Isotype

IgG

Purification Method

Antigen Affinity purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.

Tested Applications

ELISA,WB,IF

Protocols

ELISA Protocol
Western Blotting(WB) Protocol
Immunofluorescence (IF) Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Customer Reviews and Q&A

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Target Background

Function

Transcriptional factor that binds to the consensus sequence 5'-[GT][AG][AGT]GGGG-3' and acts as a repressor of autophagy. Specifically represses expression of genes involved in autophagy and lysosome biogenesis/function such as MAP1LC3B, ULK1 or WIPI2. Associates with chromatin at the ITGB4 and VEGF promoters. Also acts as a transcription activator and promotes cancer cell progression and/or migration in various tumors and myelomas.

Gene References into Functions

These results suggest that ZKSCAN3 plays an important role in bladder cancer outgrowth PMID: 27447553
ZKSCAN3 appears to promote colorectal tumor progression and invasion. ZKSCAN3 may facilitate hepatic metastasis of CRC associated with CEA particularly in cases with CEA-producing tumor PMID: 27127149
Suggest ZKSCAN3 as an autophagy master switch regulating the expression of a transcriptional network of genes integral to autophagy and lysosome biogenesis/function. PMID: 23434374
ZKSCAN3 induction represents a mechanism by which myeloma cells can induce cyclin D2 dysregulation and contribute to disease pathogenesis. PMID: 21057542
ZKSCAN3 adds to an expanding set of encoded products contributing to the progression of colorectal cancer PMID: 18519692
ZKSCAN3 regulates the expression of several genes favoring tumor progression including integrin beta 4 and VEGF PMID: 18940803

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Subcellular Location

Nucleus. Cytoplasm. Note=Mainly localizes in the nucleus. Under starvation conditions translocates to the cytoplasm, allowing expression of target genes involved in autophagy and lysosome biogenesis/function.

Protein Families

Krueppel C2H2-type zinc-finger protein family

Database Links

HGNC: 13853

OMIM: 612791

KEGG: hsa:80317

STRING: 9606.ENSP00000252211

UniGene: Hs.380930

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Service

Phage Display Service

Antibody Service

Protein Service

Gene Synthesis Service

Oligo Synthesis Service

The Overview of Autophagy Antibody FAQs What Is an Antibody? How to Choose an Antibody for Scientific Research? The difference between primary antibody and secondary antibod The Meaning of Irregular Antibody Screening Tag Antibodies, Your Good Partner in Protein Research How to Choose the Loading Control Antibodies?

Call us

301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)

[email protected]

Address

7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA

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