Name: ZMYND11 Antibody
Brand: CUSABIO
SKU: CSB-PA621870LA01HU

Product Details

Full Product Name

Rabbit anti-Homo sapiens (Human) ZMYND11 Polyclonal antibody

Uniprot No.

Q15326

Target Names

ZMYND11

Alternative Names

ZMYND11 antibody; BRAM1 antibody; BS69 antibody; Zinc finger MYND domain-containing protein 11 antibody; Adenovirus 5 E1A-binding protein antibody; Bone morphogenetic protein receptor-associated molecule 1 antibody; Protein BS69 antibody

Raised in

Rabbit

Species Reactivity

Human, Mouse

Immunogen

Recombinant Human Zinc finger MYND domain-containing protein 11 protein (363-513AA)

Immunogen Species

Homo sapiens (Human)

Conjugate

Non-conjugated

The ZMYND11 Antibody (Product code: CSB-PA621870LA01HU) is Non-conjugated. For ZMYND11 Antibody with conjugates, please check the following table.

Conjugate	Product Code	Product Name	Application
HRP	CSB-PA621870LB01HU	ZMYND11 Antibody, HRP conjugated	ELISA
FITC	CSB-PA621870LC01HU	ZMYND11 Antibody, FITC conjugated
Biotin	CSB-PA621870LD01HU	ZMYND11 Antibody, Biotin conjugated	ELISA

Clonality

Polyclonal

Isotype

IgG

Purification Method

>95%, Protein G purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4

Form

Liquid

Tested Applications

ELISA, WB, IF

Recommended Dilution

Application	Recommended Dilution
WB	1:500-1:5000
IF	1:50-1:200

Protocols

ELISA Protocol
Western Blotting(WB) Protocol
Immunofluorescence (IF) Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Usage

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

Related Products

Target Background

Function

Chromatin reader that specifically recognizes and binds histone H3.3 trimethylated at 'Lys-36' (H3.3K36me3) and regulates RNA polymerase II elongation. Does not bind other histone H3 subtypes (H3.1 or H3.2). Colocalizes with highly expressed genes and functions as a transcription corepressor by modulating RNA polymerase II at the elongation stage. Binds non-specifically to dsDNA. Acts as a tumor-suppressor by repressing a transcriptional program essential for tumor cell growth.; (Microbial infection) Inhibits Epstein-Barr virus EBNA2-mediated transcriptional activation and host cell proliferation, through direct interaction.

Gene References into Functions

The ZMYND11 gene has important functions in epigenetic regulation. PMID: 28933030
Taken together, ZMYND11 was demonstrated to be a potential and extremely promising suppressor of GBM, while miRNA-196a-5p was quite an important target of treatment of GBM. PMID: 29066350
Interaction with ZMYND11 mediates opposing roles of Ras-responsive ETS1 and ETS2. PMID: 28119415
In this study, we show that this translocation results in an in-frame translocation fusing exon 12 of the tumor suppressor gene ZMYND11 to exon 3 of the chromatin protein MBTD1, encoding a protein of 1,054 amino acids PMID: 26608508
ZMYND11 represses gene expression by binding H3.3K36me3 and preventing transcription elongation. PMID: 24795016
We propose that BS69 specifically associates with H3K36me3-enriched chromatin through the PWWP domain, which facilitates the recruitment of MYND-bound transcription and chromatin remodeling factors PMID: 24675531
this study identifies an H3.3K36me3-specific reader and a regulator of intron retention and reveals that BS69 connects histone H3.3K36me3 to regulated RNA splicing, providing significant, important insights into chromatin regulation of pre-mRNA processing. PMID: 25263594
identification of ZMYND11 as an H3.3-specific reader of H3K36me3 that links the histone-variant-mediated transcription elongation control to tumor suppression PMID: 24590075
BRAM1 acts as a negative signal regulator located at the very proximal end of lymphotoxin beta receptor complex assembly. PMID: 20732415
Data show significant association between the copy number variations of BS69 and some hematological malignancies. PMID: 20425112
Data found that BS69 directly interacted with TRAF3, a negative regulator of NF-kappaB activation. Results revealed that TRAF3 was involved in the BS69-mediated suppression of LMP1/CTAR1-induced NF-kappaB activation. PMID: 20138174
BS69 forms oligomers. The PHD and MYND domains are important for the cellular localization of BS69. PIAS1 and Ubc9 interact with BS69 and promote the sumoylation of BS69. BS69 plays inhibitory roles in both muscle and neuron differentiation. PMID: 19766626
the C-terminal Mynd domain of BS69 (amino acids 516-561) or Mynd domains of the Caenorhabditis elegans proteins Bra-1 and Bra-2 bind not only to E1A but also to the Epstein-Barr virus EBNA2 oncoprotein and the Myc-related cellular protein MGA PMID: 11733528
BS69 controls E1A stability via inhibition of ubiquitination. PMID: 16300738
The recruitment and aggregation of BS69 is a prerequisite for JNK activation by LMP1. PMID: 16382137
BS69 has roles in gene repression and chromatin remodeling PMID: 16565076
Data indicate that BS69 is involved in cellular senescence mainly through the p53-p21Cip1 pathway. PMID: 17721438
Knockdown of BS69 resulted in a decrease of IFN-beta induction, suggesting that BS69 is a positive regulator for the TLR3-TICAM-1 pathway and negative regulatory properties in NF-kappaB activation. PMID: 19795416
The adenovirus E1A binding protein BS69 is a corepressor of transcription through recruitment of N-CoR. PMID: 10734313

Hide All

Involvement in disease

Mental retardation, autosomal dominant 30 (MRD30)

Subcellular Location

Nucleus. Chromosome.

Tissue Specificity

Ubiquitous.

Database Links

HGNC: 16966

OMIM: 608668

KEGG: hsa:10771

STRING: 9606.ENSP00000371003

UniGene: Hs.292265

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Code	CSB-PA621870LA01HU
Size	US$166
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Image	Western Blot Positive WB detected in: NIH/3T3 whole cell lysate All lanes: ZMYND11 antibody at 3μg/ml Secondary Goat polyclonal to rabbit IgG at 1/50000 dilution Predicted band size: 71, 65, 67, 61 kDa Observed band size: 71 kDa Immunofluorescent analysis of A549 cells using CSB-PA621870LA01HU at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)
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ZMYND11 Antibody

Product Details

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Customer Reviews and Q&A

Target Background