ZNF268 Antibody, Biotin conjugated

1. The nuclear localization activity of KRAB domain is a conserved feature of ZNF268. PMID: 23665872
2. These results reveal a novel role of ZNF268b2 that contributes to cervical carcinogenesis in part through enhancing NF-kappaB signaling. PMID: 23091055
3. ZNF268 is a crucial downstream target and effector of GATA-1 PMID: 22235304
4. This protein has a conserved KRAB domain which localizes to the nucleus and has transcriptional repressor activity. PMID: 12822888
5. ZNF268 plays a role in early human liver development most likely by functioning through a cytoplasmic mechanism PMID: 15547661
6. 4 alternative transcripts of ZNF268 were detected in the human blood cells. PMID: 16735226
7. ZNF268 gene promoter is atypical and requires an intragenic element located within the first exon that mediates the effect of CREB for its activity PMID: 16787922
8. ZNF268 gene may function as a transcriptional activator in the growth and differentiation of cells in development and/or pathogenesis. PMID: 16865230
9. HTLV-1 oncoprotein tax represses ZNF268 expression through the cAMP-responsive element-binding PMID: 18375384
10. results indicate that a spliced form of ZNF268 lacking the KRAB domain is located in the cytosol, where it seems to play a role in TNF-alpha-induced NF-kappaB activation by interacting with the IKK complex. PMID: 18677094
11. Results demonstrate that the mammalian gene ZNF268 is regulated by hUpf1 via its promoter. PMID: 18774934
12. aberrant alternative splicing of ZNF268 is a potential prognostic factor of and may contribute to human hematological malignancies. PMID: 18949428

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HGNC: 13061

OMIM: 604753

KEGG: hsa:10795

STRING: 9606.ENSP00000228289

UniGene: Hs.124047