ZNF281 Antibody, HRP conjugated

Code CSB-PA026637LB01HU
Size US$166
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Product Details

Full Product Name
Rabbit anti-Homo sapiens (Human) ZNF281 Polyclonal antibody
Uniprot No.
Target Names
ZNF281
Alternative Names
GC box binding zinc finger protein 1 antibody; GC-box-binding zinc finger protein 1 antibody; GZP1 antibody; Transcription factor ZBP-99 antibody; ZBP 99 antibody; ZBP99 antibody; zfp281 antibody; Zinc finger DNA binding protein 99 antibody; Zinc finger DNA-binding protein 99 antibody; Zinc finger protein 281 antibody; ZN281_HUMAN antibody; ZNF281 antibody; ZNP 99 antibody; ZNP 99 transcription factor antibody; ZNP99 antibody
Raised in
Rabbit
Species Reactivity
Human
Immunogen
Recombinant Human Zinc finger protein 281 protein (1-300AA)
Immunogen Species
Homo sapiens (Human)
Conjugate
HRP
Clonality
Polyclonal
Isotype
IgG
Purification Method
Antigen Affinity Purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
Form
Liquid
Tested Applications
ELISA
Protocols
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
Transcription repressor that plays a role in regulation of embryonic stem cells (ESCs) differentiation. Required for ESCs differentiation and acts by mediating autorepression of NANOG in ESCs: binds to the NANOG promoter and promotes association of NANOG protein to its own promoter and recruits the NuRD complex, which deacetylates histones. Not required for establishement and maintenance of ESCs. Represses the transcription of a number of genes including GAST, ODC1 and VIM. Binds to the G-rich box in the enhancer region of these genes.
Gene References into Functions
  1. These observations suggest that ZNF281 is a controller of neuronal differentiation that should be evaluated as a prognostic marker in neuroblastoma. PMID: 29941555
  2. involvement of ZNF281 in the cellular response to genotoxic stress through the control exercised on the expression of genes that act in different repair mechanisms PMID: 26300006
  3. High ZNF281 expression is associated with colon and breast cancer. PMID: 24185900
Subcellular Location
Nucleus.
Protein Families
Krueppel C2H2-type zinc-finger protein family
Database Links

HGNC: 13075

KEGG: hsa:23528

STRING: 9606.ENSP00000294740

UniGene: Hs.59757

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