ZNF350 Antibody

1. Results indicate ZNF350 as an important gene mammary oncogenesis. PMID: 29653063
2. Results indicated that SNP rs2278414 at ZNF350 may in fl uence an individual's susceptibility to age-related cataract (ARC) by affecting the binding af fi nity of miR-21-3p and miR-150-5p and regulating expression levels of the mRNAs, resulting in different levels of cellular DNA breaks, thus contributing to ARC. PMID: 27586871
3. villin directly interacts with a transcriptional corepressor and ligand of the Slug promoter, ZBRK1. PMID: 26658611
4. ZBRK1 suppresses renal cancer progression perhaps by regulating VHL expression through formation of a complex with VHL and p300 in renal cancer PMID: 25749518
5. MAGE proteins bind to KAP1, a gene repressor and ubiquitin E3 ligase which also binds KRAB domain containing zinc finger transcription factors (KZNFs), and MAGE expression may affect KZNF mediated gene regulation. PMID: 25107531
6. The secondary structure of the ZBRK1-DNA complex is found to be significantly altered from the standard B-DNA conformation. PMID: 24924633
7. results indicate that a loss of ZBRK1 contributes to the increased expression of KAP1, potentiating its role to enhance metastasis and invasion PMID: 23991171
8. promoter assays in two breast cancer cell lines identified two haplotypes (H11 and H12) stimulating significantly the expression of ZNF350 transcript compared with the common haplotype H8 PMID: 23151675
9. ZBRK1 negatively regulates the HIV-1 LTR PMID: 22975076
10. high levels of gene activity in the genomic environment and the pre-deposition of repressive histone marks within a gene increase its susceptibility to KRAB/KAP1-mediated repression PMID: 21791101
11. KRAB-containing zinc-finger transcriptional regulator, ZBRK1, an interaction partner of the SCA2 gene product ataxin-2. PMID: 20926453
12. RB.E2F1 complex plays a critical role in ZBRK1 transcriptional repression, and loss of this repression may contribute to cellular sensitivity of DNA damage, ultimately leading to carcinogenesis. PMID: 20713352
13. Data found that HMGA2, along with a dozen of other genes, was co-repressed by ZBRK1, BRCA1, and CtIP. PMID: 20007691
14. KRAB/KAP1 recruitment induces long-range repression through the spread of heterochromatin. PMID: 20221260
15. Our findings suggest that ZBRK1 acts to inhibit metastasis of cervical carcinoma, perhaps by modulating MMP9 expression. PMID: 19996286
16. ZBRK1 mutation found in BRCA1 and BRCA2 mutation negative probands with breast or ovarian cancer. PMID: 12872252
17. ZBRK1 is a novel target for DNA damage-induced degradation PMID: 14517299
18. ZBRK1 zinc fingers have dual roles in sequence-specific DNA-binding and BRCA1-dependent transcriptional repression PMID: 14660588
19. the CTRD is a novel protein interaction surface responsible for directing homotypic and heterotypic interactions necessary for ZBRK1-directed transcriptional repression PMID: 15496401
20. interacts with BBLF2/3 to provide a tethering point on oriLyt for the EBV replication complex PMID: 15596820
21. KRAB-induced transcriptional repression is robust and active over a variety of genomic contexts that include at least the wide range of sites targeted by lentiviral integration PMID: 16997916
22. Genetic variants and haplotypes of the ZBRK1 gene is associated with breast and ovarian cancer PMID: 17764113
23. KRAB/KAP1 regulation is fully functional within the context of episomal DNA PMID: 19279087
24. BRCA1 and ZNF350 may jointly contribute to individuals' susceptibility of breast cancer in Chinese women. PMID: 19484476

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HGNC: 16656

OMIM: 605422

KEGG: hsa:59348

STRING: 9606.ENSP00000243644

UniGene: Hs.407694