ZP1 Antibody

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Datasheet

Code	CSB-PA140644
Size	US$297
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Image	Western blot analysis of extracts from LOVO cells, using ZP1 antibody.
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Product Details
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Target Background

Product Details

Full Product Name

Rabbit anti-Homo sapiens (Human) ZP1 Polyclonal antibody

Uniprot No.

P60852

Target Names

ZP1

Alternative Names

MGC87693 antibody; Processed zona pellucida sperm-binding protein 1 antibody; zona pellucida glycoprotein 1 (sperm receptor) antibody; Zona pellucida glycoprotein 1 antibody; zona pellucida protein 1 antibody; Zp 1 antibody; Zp-1 antibody; Zp1 antibody; ZP1_HUMAN antibody

Raised in

Rabbit

Species Reactivity

Human

Immunogen

Synthesized peptide derived from internal of Human ZP1.

Immunogen Species

Homo sapiens (Human)

Clonality

Polyclonal

Purification Method

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration

It differs from different batches. Please contact us to confirm it.

Form

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Tested Applications

ELISA,WB

Recommended Dilution

Application	Recommended Dilution
WB	1:500-1:3000

Protocols

ELISA Protocol
Western Blotting(WB) Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Customer Reviews and Q&A

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Target Background

Function

Component of the zona pellucida, an extracellular matrix surrounding oocytes which mediates sperm binding, induction of the acrosome reaction and prevents post-fertilization polyspermy. The zona pellucida is composed of 3 to 4 glycoproteins, ZP1, ZP2, ZP3, and ZP4. ZP1 ensures the structural integrity of the zona pellucida.

Gene References into Functions

this study identified a homozygous frameshift mutation in ZP1 in six family members with a form of infertility with an autosomal recessive mode of inheritance. PMID: 24670168
observed sequence variations in exons of ZP1 gene in women with infertility of unknown origin who exhibit abnormal zona pellucida; sperm-ovum interactions appear relatively normal in these patients [CASE REPORTS] PMID: 22889493
The 'ZP domain' module of human ZP1 has functional activity and may have a role during fertilization in humans. PMID: 20831819
ZP1 binds to capacitated spermatozoa and induces acrosomal exocytosis. PMID: 20504872
ZP proteins were detected in both the oocyte and the granulosa cells as early as the primordial follicle stage in the human. The detection of ZP proteins in the quiescent primordial follicle suggests that these proteins have been present since oogenesis. PMID: 18033806

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Involvement in disease

Oocyte maturation defect 1 (OOMD1)

Subcellular Location

[Processed zona pellucida sperm-binding protein 1]: Zona pellucida.; Cell membrane; Single-pass type I membrane protein.

Protein Families

ZP domain family, ZPB subfamily

Tissue Specificity

Expressed in oocytes (at protein level).

Database Links

HGNC: 13187

OMIM: 195000

KEGG: hsa:22917

STRING: 9606.ENSP00000278853

UniGene: Hs.172130

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Antibody FAQs What Is an Antibody? How to Choose an Antibody for Scientific Research? The difference between primary antibody and secondary antibod The Meaning of Irregular Antibody Screening Tag Antibodies, Your Good Partner in Protein Research How to Choose the Loading Control Antibodies?

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301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)

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7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA

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