ZP4 Antibody, Biotin conjugated

Datasheet

Code	CSB-PA621518LD01HU
Size	US$166
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Target Background

Product Details

Full Product Name

Rabbit anti-Homo sapiens (Human) ZP4 Polyclonal antibody

Uniprot No.

Q12836

Target Names

ZP4

Alternative Names

Processed zona pellucida sperm-binding protein 4 antibody; ZBP antibody; Zona pellucida B protein antibody; Zona pellucida glycoprotein 4 antibody; Zona pellucida protein B antibody; Zona pellucida sperm binding protein 4 antibody; Zp-4 antibody; ZP1 antibody; ZP4 antibody; ZP4_HUMAN antibody; ZPB antibody

Raised in

Rabbit

Species Reactivity

Human

Immunogen

Recombinant Human Zona pellucida sperm-binding protein 4 protein (368-457AA)

Immunogen Species

Homo sapiens (Human)

Conjugate

Biotin

Clonality

Polyclonal

Isotype

IgG

Purification Method

>95%, Protein G purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4

Form

Liquid

Tested Applications

ELISA

Protocols

ELISA Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function

Component of the zona pellucida, an extracellular matrix surrounding oocytes which mediates sperm binding, induction of the acrosome reaction and prevents post-fertilization polyspermy. The zona pellucida is composed of 3 to 4 glycoproteins, ZP1, ZP2, ZP3, and ZP4. ZP4 may act as a sperm receptor.

Gene References into Functions

ZO4 is highly expressed in ovarian tissue in PCOS patients with regular cycle and without hyperandrogenism; in some patients with PCOS and infertility, ZP4 mutation can be found. PMID: 25740067
Human ZP4 is not sufficient to support human sperm binding to the zona pellucida in transgenic mice; other zona proteins may be needed for human gamete recognition. PMID: 21173071
ZPB induces acrosomal exocytosis through a Gi independent pathway. PMID: 15805145
Binding sites for recombinant zona pellucida B (ZPB) glycoprotein are located both at the N- and C-terminus of proacrosin PMID: 15950651
Exposure of sperm to ZP proteins promoted acrosomal exocytosis and changed motility patterns. PMID: 16407501
induces acrosome reactions which are protein kinase-C, protein tyrosine kinase, T-type Ca2+ channels, and extracellular Ca2+ dependent PMID: 18667750
a significant decrease in acrosomal exocytosis mediated by both recombinant human ZP3 (p<0.005) and ZP4 (p<0.005) was observed in presence of the immune sera PMID: 19004505

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Subcellular Location

[Processed zona pellucida sperm-binding protein 4]: Zona pellucida.; Cell membrane; Single-pass type I membrane protein.

Protein Families

ZP domain family, ZPB subfamily

Tissue Specificity

Expressed in oocytes.

Database Links

HGNC: 15770

OMIM: 613514

KEGG: hsa:57829

STRING: 9606.ENSP00000355529

UniGene: Hs.136241

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Antibody FAQs What Is an Antibody? How to Choose an Antibody for Scientific Research? The difference between primary antibody and secondary antibod The Meaning of Irregular Antibody Screening Tag Antibodies, Your Good Partner in Protein Research How to Choose the Loading Control Antibodies?

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