Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Cooperates with CIITA to promote transcription of MHC class I and MHC class II genes.
Gene References into Functions
Data show that ZXDC1 is a regulator in the process of myeloid function and that ZXDC1 is responsible for Ccl2 gene de-repression by BCL6. PMID: 23954399
Role of ZXD proteins in regulating MHC II transcription. PMID: 19777325
ZXDC is an important regulator of both MHC class I and class II transcription PMID: 16600381
ZXDA and ZXDC form an important regulatory complex for MHC II gene transcription. PMID: 17493635
study found sumoylation does not appear to disrupt or modulate interaction of ZXDC with binding partners; sumoylation of ZXDC is required for full activity of transcriptional activation domain; study suggests sumoylation is an important regulator of ZXDC PMID: 17696781
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Subcellular Location
Nucleus.
Protein Families
ZXD family
Tissue Specificity
Expressed at high levels in heart, kidney, liver and testis, at moderate levels in brain and stomach, and at low levels in lung, muscle, placenta, small intestine and spleen.