cyp26b1 Antibody

Code CSB-PA721935LA01DIL
Size US$166
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  • Western Blot
    Positive WB detected in Recombinant protein
    All lanes: cyp26b1 antibody at 4.4µg/ml
    Secondary
    Goat polyclonal to rabbit IgG at 1/50000 dilution
    Predicted band size: 46 kDa
    Observed band size: 51 kDa
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Product Details

Full Product Name
Rabbit anti-Zebrafish cyp26b1 Polyclonal antibody
Uniprot No.
Target Names
cyp26b1
Alternative Names
cyp26b1Cytochrome P450 26B1 antibody; Cyp26B1 antibody; EC 1.14.13.- antibody; Retinoic acid-metabolizing cytochrome antibody
Raised in
Rabbit
Species Reactivity
Zebrafish
Immunogen
Recombinant Zebrafish Cytochrome P450 26B1 protein (366-511AA)
Immunogen Species
Zebrafish
Conjugate
Non-conjugated

The cyp26b1 Antibody (Product code: CSB-PA721935LA01DIL) is Non-conjugated. For cyp26b1 Antibody with conjugates, please check the following table.

Available Conjugates
Conjugate Product Code Product Name Application
HRP CSB-PA721935LB01DIL cyp26b1 Antibody, HRP conjugated ELISA
FITC CSB-PA721935LC01DIL cyp26b1 Antibody, FITC conjugated
Biotin CSB-PA721935LD01DIL cyp26b1 Antibody, Biotin conjugated ELISA
Clonality
Polyclonal
Isotype
IgG
Purification Method
>95%, Protein G purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Form
Liquid
Tested Applications
ELISA, WB
Recommended Dilution
Application Recommended Dilution
WB 1:500-1:5000
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
Involved in the metabolism of retinoic acid (RA), rendering this classical morphogen inactive through oxidation. Appears to be involved in the inactivation of all-trans-retinoic acid (RA). Plays a role in skeletal development.
Gene References into Functions
  1. we find that Cyp26 function is required in a short time window that overlaps the dynamic window of tenoblast condensation. However, cyp26b1 expression is largely restricted to regions between tenoblast condensations during this time PMID: 29227993
  2. The data demonstrate that RA-induced osteoblast-preosteocyte transitioning has multiple effects on developing bone in Cyp26b1 mutants, ranging from gain to loss of bone, depending on the allelic strength, the developmental stage and the cellular context. PMID: 26903503
  3. cyp26b1 is involved in limiting the activity of retinoic acid. Zygotic cyp26b1 was localized to presumptive rhombomere 3 and rhombomere 4 at early two-somite (2S) stage. Expression expands anteriorly to include rhombomere 2 at the 10S stage. PMID: 15661642
  4. effects of the inhibitor rather than excess retinoic acid most closely phenocopied the jaw defects seen with the Cyp26B1 morpholino PMID: 17616924
  5. Cyp26b1 is expressed within osteoblast cells, demonstrating that retinoic acid levels within these cells need to be tightly controlled PMID: 18927155
  6. cyp26b1 mutants may serve as a model to study the etiology of human vertebral disorders such as Klippel-Feil anomaly PMID: 18927157

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Subcellular Location
Endoplasmic reticulum membrane; Peripheral membrane protein. Microsome membrane; Peripheral membrane protein.
Protein Families
Cytochrome P450 family
Database Links
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