lktA Antibody

Code CSB-PA314743EA01ESE
Size US$299
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Product Details

Full Product Name Rabbit anti-Mannheimia haemolytica lktA Polyclonal antibody
Uniprot No. P0C085
Target Names lktA
Alternative Names lktA antibody; Leukotoxin antibody; Lkt antibody
Raised in Rabbit
Species Reactivity Mannheimia haemolytica
Immunogen Recombinant Mannheimia haemolytica Leukotoxin protein (715-953AA)
Immunogen Species Mannheimia haemolytica
Conjugate Non-conjugated
Clonality Polyclonal
Isotype IgG
Purification Method >95%, Protein G purified
Concentration It differs from different batches. Please contact us to confirm it.
Buffer Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
Form Liquid
Tested Applications ELISA
Protocols ELISA Protocol
Troubleshooting and FAQs Antibody FAQs
Storage Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Applications : WB

Sample type: goats and lambs

Review: Mannheimia haemolytica (Mha) culture growth and Lkt secretion profile. (a): SDS page of Mha culture supernatant samples. (b): Anti-Lkt Western blot of Mha culture supernatant samples. SM: Molecular weight marker(color protein standard broad range P7712S Biolabs).

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Target Background

Function
(From Uniprot)
Pasteurella leukotoxins are exotoxins that attack host leukocytes and especially polymorphonuclear cells, by causing cell rupture. The leukotoxin binds to the host LFA-1 integrin and induces a signaling cascade leading to many biological effects, including tyrosine phosphorylation of the CD18 tail, elevation of the intracellular Ca(2+) and lysis of the host cell (By similarity). This leukotoxin is a major contributor to the pathogenesis of lung injury in ovine pneumonic pasteurellosis. It has also weak hemolytic activity.
Subcellular Location Secreted, Host cell membrane, Multi-pass membrane protein
Protein Families RTX prokaryotic toxin (TC 1.C.11) family

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