vcp Antibody, HRP conjugated

Code CSB-PA772050LB01DIL
Size US$299 How to order?
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Product Details

Full Product Name Rabbit anti-Zebrafish vcp Polyclonal antibody
Uniprot No. Q7ZU99
Target Names vcp
Alternative Names vcp antibody; cdc48 antibody; si:ch211-113n10.2Transitional endoplasmic reticulum ATPase antibody; TER ATPase antibody; EC 3.6.4.6 antibody; Protein CDC48 antibody; Valosin-containing protein antibody; VCP antibody
Raised in Rabbit
Species Reactivity Zebrafish
Immunogen Recombinant Zebrafish Transitional endoplasmic reticulum ATPase protein (704-806AA)
Immunogen Species Zebrafish
Conjugate HRP
Clonality Polyclonal
Isotype IgG
Purification Method >95%, Protein G purified
Concentration It differs from different batches. Please contact us to confirm it.
Buffer Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Form Liquid
Tested Applications ELISA
Protocols ELISA Protocol
Troubleshooting and FAQs Antibody FAQs
Storage Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
Necessary for the fragmentation of Golgi stacks during mitosis and for their reassembly after mitosis. Involved in the formation of the nuclear envelope, and of the transitional endoplasmic reticulum (tER). The transfer of membranes from the endoplasmic reticulum to the Golgi apparatus occurs via 50-70 nm transition vesicles which derive from part-rough, part-smooth transitional elements of the endoplasmic reticulum (tER). Vesicle budding from the tER is an ATP-dependent process. Also involved in DNA damage response: recruited to double-strand breaks (DSBs) sites and promotes the recruitment of tp53bp1 at DNA damage sites. Together with sprtn metalloprotease, involved in the repair of covalent DNA-protein cross-links (DPCs) during DNA synthesis. Involved in interstrand cross-link repair in response to replication stress by mediating unloading of the ubiquitinated CMG helicase complex. Enhances cell cycle progression and inhibits apoptosis at low temperatures. Essential for the maturation of ubiquitin-containing autophagosomes and the clearance of ubiquitinated protein by autophagy. Acts as a negative regulator of type I interferon production by promoting ubiquitination of ddx58/rig-i. May play a role in the ubiquitin-dependent sorting of membrane proteins to lysosomes where they undergo degradation. May more particularly play a role in caveolins sorting in cells. By controlling the steady-state expression of the IGF1R receptor, indirectly regulates the insulin-like growth factor receptor signaling pathway.
Gene References into Functions
  1. When we introduced CDC48 antisense morpholino oligonucleotides into zebrafish embryos, the morphant embryos were lethal and showed defects in neuronal outgrowth and neurodegeneration. PMID: 22549779
  2. CDC48 may promote cell cycling and cell proliferation via C-terminal tyrosine phosphorylation during cold acclimation in fish cells PMID: 12914916
Subcellular Location Cytoplasm, cytosol. Endoplasmic reticulum. Nucleus.
Protein Families AAA ATPase family
Database Links

KEGG: dre:327197

STRING: 7955.ENSDARP00000012048

UniGene: Dr.75122

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