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Code | CSB-PA325553LA01HLU |
Size | US$299 |
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Full Product Name | Rabbit anti-Human immunodeficiency virus type 2 subtype A (isolate BEN) (HIV-2) vpx Polyclonal antibody |
Uniprot No. | P18099 |
Target Names | vpx |
Alternative Names | vpxProtein Vpx antibody; Viral protein X antibody; X ORF protein antibody |
Raised in | Rabbit |
Species Reactivity | Human immunodeficiency virus type 2 subtype A |
Immunogen | Recombinant Human immunodeficiency virus type 2 subtype A Protein Vpx protein (1-113AA) |
Immunogen Species | Human immunodeficiency virus type 2 subtype A (isolate BEN) (HIV-2) |
Conjugate | Non-conjugated The vpx Antibody (Product code: CSB-PA325553LA01HLU) is Non-conjugated. For vpx Antibody with conjugates, please check the following table. |
Clonality | Polyclonal |
Isotype | IgG |
Purification Method | >95%, Protein G purified |
Concentration | It differs from different batches. Please contact us to confirm it. |
Buffer | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 |
Form | Liquid |
Tested Applications | ELISA |
Protocols | ELISA Protocol |
Troubleshooting and FAQs | Antibody FAQs |
Storage | Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. |
Lead Time | Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time. |
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Function |
Plays a role in nuclear translocation of the viral pre-integration complex (PIC), thus is required for the virus to infect non-dividing cells. Targets specific host proteins for degradation by the 26S proteasome. Acts by associating with the cellular CUL4A-DDB1 E3 ligase complex through direct interaction with host VPRPB/DCAF-1. This change in the E3 ligase substrate specificity results in the degradation of host SAMHD1. In turn, SAMHD1 depletion allows viral replication in host myeloid cells by preventing SAMHD1-mediated hydrolysis of intracellular dNTPs necessary for reverse transcription.
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Gene References into Functions |
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Subcellular Location | Virion. Host nucleus. |
Protein Families | Lentivirus VPX protein family |
Database Links |
KEGG: vg:1724714 |