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| Code | CSB-PA325553LA01HLU |
| See More Details |  |
| Size | US$299 |
| Uniprot No. | P18099 |
| Protocols | ELISA Protocol |
| Immunogen | Recombinant Human immunodeficiency virus type 2 subtype A Protein Vpx protein (1-113AA) |
| Raised in | Rabbit |
| Species Reactivity | Human immunodeficiency virus type 2 subtype A |
| Tested Applications | ELISA |
| Relevance | Plays a role in nuclear translocation of the viral pre-integration complex (PIC), thus is required for the virus to infect non-dividing cells. Targets specific host proteins for degradation by the 26S proteasome. Acts by associating with the cellular CUL4A-DDB1 E3 ligase complex through direct interaction with host VPRPB/DCAF-1. This change in the E3 ligase substrate specificity results in the degradation of host SAMHD1. In turn, SAMHD1 depletion allows viral replication in host myeloid cells by preventing SAMHD1-mediated hydrolysis of intracellular dNTPs necessary for reverse transcription. |
| Form | Liquid |
| Conjugate | Non-conjugated |
| Storage Buffer | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 |
| Purification Method | >95%, Protein G purified |
| Isotype | IgG |
| Clonality | Polyclonal |
| Alias | Protein Vpx (Viral protein X) (X ORF protein), vpx |
| Immunogen Species | Human immunodeficiency virus type 2 subtype A (isolate BEN) (HIV-2) |
| Research Area | Others |
| Target Names | vpx |
| Storage | Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. |
| Still Have Questions? | Leave a Message or Start an on-line Chat |
| Function | Plays a role in nuclear translocation of the viral pre-integration complex (PIC), thus is required for the virus to infect non-dividing cells. Targets specific host proteins for degradation by the 26S proteasome. Acts by associating with the cellular CUL4A-DDB1 E3 ligase complex through direct interaction with host VPRPB/DCAF-1. This change in the E3 ligase substrate specificity results in the degradation of host SAMHD1. In turn, SAMHD1 depletion allows viral replication in host myeloid cells by preventing SAMHD1-mediated hydrolysis of intracellular dNTPs necessary for reverse transcription. |
| Subcellular Location | Virion, Host nucleus |
| Protein Families | Lentivirus VPX protein family |
| Database Links |
KEGG: vg:1724714 |
vpx Antibodies for Human immunodeficiency virus type 2 subtype A (isolate BEN) (HIV-2)
| Code | Product Name | Species Reactivity | Application |
|---|---|---|---|
| CSB-PA325553LB01HLU | vpx Antibody, HRP conjugated | Human immunodeficiency virus type 2 subtype A | ELISA |
| CSB-PA325553LC01HLU | vpx Antibody, FITC conjugated | Human immunodeficiency virus type 2 subtype A | ELISA |
| CSB-PA325553LD01HLU | vpx Antibody, Biotin conjugated | Human immunodeficiency virus type 2 subtype A | ELISA |
vpx Proteins for Human immunodeficiency virus type 2 subtype A (isolate BEN) (HIV-2)
| Code | Product Name | Source |
|---|---|---|
| CSB-YP325553HLU CSB-BP325553HLU CSB-MP325553HLU |
Recombinant Human immunodeficiency virus type 2 subtype A Protein Vpx(vpx) | Yeast Baculovirus Mammalian cell |
| CSB-EP325553HLU | Recombinant Human immunodeficiency virus type 2 subtype A Protein Vpx(vpx) | E.coli |
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