vpx Antibody, FITC conjugated

Datasheet
Code CSB-PA325553LC01HLU
Size US$299
Uniprot No. P18099
Protocols ELISA Protocol
Immunogen Recombinant Human immunodeficiency virus type 2 subtype A Protein Vpx protein (1-113AA)
Raised in Rabbit
Species Reactivity Human immunodeficiency virus type 2 subtype A
Tested Applications ELISA
Relevance Plays a role in nuclear translocation of the viral pre-integration complex (PIC), thus is required for the virus to infect non-dividing cells. Targets specific host proteins for degradation by the 26S proteasome. Acts by associating with the cellular CUL4A-DDB1 E3 ligase complex through direct interaction with host VPRPB/DCAF-1. This change in the E3 ligase substrate specificity results in the degradation of host SAMHD1. In turn, SAMHD1 depletion allows viral replication in host myeloid cells by preventing SAMHD1-mediated hydrolysis of intracellular dNTPs necessary for reverse transcription.
Form Liquid
Conjugate FITC
Storage Buffer Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
Purification Method >95%, Protein G purified
Isotype IgG
Clonality Polyclonal
Alias Protein Vpx (Viral protein X) (X ORF protein), vpx
Immunogen Species Human immunodeficiency virus type 2 subtype A (isolate BEN) (HIV-2)
Research Area Others
Target Names vpx
Storage Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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Function Plays a role in nuclear translocation of the viral pre-integration complex (PIC), thus is required for the virus to infect non-dividing cells. Targets specific host proteins for degradation by the 26S proteasome. Acts by associating with the cellular CUL4A-DDB1 E3 ligase complex through direct interaction with host VPRPB/DCAF-1. This change in the E3 ligase substrate specificity results in the degradation of host SAMHD1. In turn, SAMHD1 depletion allows viral replication in host myeloid cells by preventing SAMHD1-mediated hydrolysis of intracellular dNTPs necessary for reverse transcription.
Subcellular Location Virion, Host nucleus
Protein Families Lentivirus VPX protein family
Database Links

KEGG: vg:1724714

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