Recombinant Bovine Growth/differentiation factor 8 (MSTN)

1. GH/HpaII locus as candidate marker for body weight in cattle rather than MSTN/DraI. PMID: 29023020
2. Data indicate that the the promoter trap vector PIII-myostatin could knock out the bovine myostatin gene. PMID: 25867424
3. The effects of myostatin and myogenic factor 5 polymorphisms on growth and muscle traits of Marchigiana breed were assessed. PMID: 25023801
4. we demonstrate zygote injection of TALEN mRNA can also produce gene-edited cattle and sheep. In both species we have targeted the myostatin (MSTN) gene. PMID: 25204701
5. proof-of-concept study is the first to produce MSTN mutations in cattle, and may allow the development of genetically modified strains of double-muscled cattle. PMID: 24743319
6. Mutations in the leader peptide of the bovine myostatin gene effectively promote the proliferation of bovine fibroblast cells. PMID: 24583167
7. there were 18 SNPs identified in the Qinchuan cattle promoter region compared with those of other cattle compared to the Red Angus cattle myostatin promoter region. PMID: 24065681
8. A 3-way interaction of myostatin genotype (MG), season, and trigonometric function periodicities of 24 h and 12 h indicate that a genotype x environment interaction exists for MG. PMID: 23572263
9. These results show for the first time that myostatin regulates the differential expression of chemokines in skeletal muscle cells. PMID: 23838214
10. bovine myostatin is a specific target of miR-27b and that miRNAs contribute to explain additive phenotypic hypertrophy in Piedmontese cattle selected for the MSTN gene mutation PMID: 23510267
11. Mutations in the myostatin gene, responsible for the double muscling condition in cattle, were targeted to estimate the time since the most recent common ancestor. Each myostatin allele had a recent common ancestor (<400 years ago). PMID: 22497537
12. MSTN promoter polymorphism g.-371T>A may affect carcass traits. PMID: 21743995
13. Expressions of C-EBPalpha and myostatin in muscles were higher in the concentrate-fed group than in the grass hay-fed group. PMID: 21641731
14. The sequence of the bovine myostatin gene promoter and first intron from Qinchuan and Red Angus cattle, was analyzed. PMID: 21125331
15. the selection of the myostatin gene "+" allele has the potential to increase conventional milk production traits in the dual-purpose Belgian Blue breed. PMID: 21700058
16. The I442M mutation in the NCAPG gene and the Q204X mutation in the GDF8 gene, were identified as substantial modulators of pre- and/or postnatal growth in cattle. PMID: 20647382
17. extracellular matrix molecules may modulate myostatin activity PMID: 20163680
18. mutations Q204X and nt821 affect carcass and meat quality PMID: 19966162
19. Northern blot analysis revealed no appreciable change in myostatin mRNA levels between proliferating myoblasts and differentiated myotubes. PMID: 15975431
20. Results suggest that myostatin auto-regulates its gene expression through a Smad7 dependent mechanism in myogenic cells. PMID: 16110474
21. myostatin loss-of-function mutation affected several physiological processes involved in the development and determination of the functional characteristics of muscle tissue PMID: 17331240
22. F94L genotype can produce an intermediate, non-double muscling phenotype, which should be of significant value for beef cattle producers. PMID: 17617213
23. The results provide strong evidence that this myostatin F94L variant provides an intermediate and more useful phenotype than the more severe double-muscling phenotype caused by knockout mutations in the myostatin gene. PMID: 18245504
24. Single-nucleotide polymorphism in the myostatin gene 5'-flanking region is associated with abnormal skeletal muscle growth and development. PMID: 18670060
25. 11-bp deletion in the bovine myostatin was found at a low frequency (0.04) with no animals homozygous for the mutation in the sample population (536 animals)in a commercial population of Scottish Aberdeen Angus beef cattle. PMID: 18822096
26. findings suggest that the endogenous myostatin preferentially down-regulates the expression of the fast 2x MyHC and participates in differentiation of myofiber types during early bovine myogenesis PMID: 18941308
27. The objective of this study was to quantify the effects of the Charolais-specific inactive myostatin allele on phenotypic means and genetic parameters of heifer breeding traits. PMID: 19213706
28. The gene expression pattern of inhibitory proteins related to MSTN signaling suggests a strong downregulation of this pathway in response to prolonged stretching. PMID: 19705480
29. DNA sequencing revealed three, seven and four polymorphisms in exons 1, 2 and 3, respectively of the myostatin gene. PMID: 19731204

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KEGG: bta:281187

STRING: 9913.ENSBTAP00000015674

UniGene: Bt.605