Recombinant Bovine Sclerostin(SOST)

Product Type Recombinant Protein
Uniprot No. Q9BG79
Abbreviation SOST
Species Bos taurus (Bovine)
Gene Names SOST
Protein Names Recommended name: Sclerostin
Storage The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
Notes Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Target Details Sclerostin is a secreted glycoprotein with a C-terminal cysteine knot-like (CTCK) domain and sequence similarity to the DAN (differential screening-selected gene aberrative in neuroblastoma) family of bone morphogenetic protein (BMP) antagonists. Loss-of-function mutations in this gene are associated with an autosomal-recessive disorder, sclerosteosis, which causes progressive bone overgrowth. A deletion downstream of this gene, which causes reduced sclerostin expression, is associated with a milder form of the disorder called van Buchem disease.
HGNC 13771
RGD 69358
MGI 1921749
Function Negative regulator of bone growth that acts through inhibition of Wnt signaling and bone formation.
Subcellular Location Secreted, extracellular space, extracellular matrix
Protein Families Sclerostin family
Database Links

STRING: 9913.ENSBTAP00000017458

UniGene: Bt.13086

Pathway Wnt signaling pathway

Product Details for Different Expression Systems

Product Name Recombinant Bovine Sclerostin(SOST),Yeast
Code CSB-YP860205BO
Size Pls inquiry other sizes
Source Yeast
Purity >85% (SDS-PAGE)
Tag Info The following tags are available.
N-terminal His-tagged
Tag-Free
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
Sequence QGWQAFK NDATEIIPEL GEYPEPLPEL NNKTMNRAEN GGRPPHHPFE TKDASEYSCR ELHFTRYVTD GPCRSAKPVT ELVCSGQCGP ARLLPNAIGR GKWWRPSGPD FRCIPDRYRA QRVQLLCPGG AAPRARKVRL VASCKCKRLT RFHNQSELKD FGPEAARPQT GRKLRPRARG TKASRAELEN AY
Expression Region 24-212
Protein Description Full Length of Mature Protein
Storage Buffer Tris-based buffer,50% glycerol
Still Have Questions? Leave a Message or Start an on-line Chat
Product Name Recombinant Bovine Sclerostin(SOST),E.coli
Code CSB-EP860205BO
Size Pls inquiry other sizes
Source E.coli
Purity >85% (SDS-PAGE)
Tag Info The following tags are available.
N-terminal His-tagged and C-terminal Myc-tagged
N-terminal His-SUMO-tagged and C-terminal Myc-tagged
N-terminal His-B2M-tagged and C-terminal Myc-tagged
N-terminal His-GST-tagged and C-terminal Myc-tagged
N-terminal His-tagged
N-terminal His-SUMO-tagged
N-terminal His-B2M-tagged
N-terminal His-GST-tagged
N-terminal GST-tagged
Tag-Free
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
Sequence QGWQAFK NDATEIIPEL GEYPEPLPEL NNKTMNRAEN GGRPPHHPFE TKDASEYSCR ELHFTRYVTD GPCRSAKPVT ELVCSGQCGP ARLLPNAIGR GKWWRPSGPD FRCIPDRYRA QRVQLLCPGG AAPRARKVRL VASCKCKRLT RFHNQSELKD FGPEAARPQT GRKLRPRARG TKASRAELEN AY
Expression Region 24-212
Protein Description Full Length of Mature Protein
Storage Buffer Tris-based buffer,50% glycerol
Still Have Questions? Leave a Message or Start an on-line Chat
Product Name Recombinant Bovine Sclerostin(SOST),Baculovirus
Code CSB-BP860205BO
Size Pls inquiry other sizes
Source Baculovirus
Purity >85% (SDS-PAGE)
Tag Info The following tags are available.
N-terminal His-tagged and C-terminal Myc-tagged
N-terminal His-tagged
Tag-Free
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
Sequence QGWQAFK NDATEIIPEL GEYPEPLPEL NNKTMNRAEN GGRPPHHPFE TKDASEYSCR ELHFTRYVTD GPCRSAKPVT ELVCSGQCGP ARLLPNAIGR GKWWRPSGPD FRCIPDRYRA QRVQLLCPGG AAPRARKVRL VASCKCKRLT RFHNQSELKD FGPEAARPQT GRKLRPRARG TKASRAELEN AY
Expression Region 24-212
Protein Description Full Length of Mature Protein
Storage Buffer Tris-based buffer,50% glycerol
Still Have Questions? Leave a Message or Start an on-line Chat
Product Name Recombinant Bovine Sclerostin(SOST),Mammalian cell
Code CSB-MP860205BO
Size Pls inquiry other sizes
Source Mammalian cell
Purity >85% (SDS-PAGE)
Tag Info The following tags are available.
N-terminal His-tagged and C-terminal Myc-tagged
N-terminal His-tagged
Tag-Free
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
Sequence QGWQAFK NDATEIIPEL GEYPEPLPEL NNKTMNRAEN GGRPPHHPFE TKDASEYSCR ELHFTRYVTD GPCRSAKPVT ELVCSGQCGP ARLLPNAIGR GKWWRPSGPD FRCIPDRYRA QRVQLLCPGG AAPRARKVRL VASCKCKRLT RFHNQSELKD FGPEAARPQT GRKLRPRARG TKASRAELEN AY
Expression Region 24-212
Protein Description Full Length of Mature Protein
Storage Buffer Tris-based buffer,50% glycerol
Still Have Questions? Leave a Message or Start an on-line Chat

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