SOST, also known as Sclerostin or VBCH, is a secretory glycoprotein encoded by the SOST gene and part of the Cerberus/Dan BMP antagonist family. It is produced by bone cells and has anti-osteogenic effects, inhibiting bone formation by binding to LRP5/6 receptors and suppressing the Wnt signaling pathway. SOST is vital for bone homeostasis, density, and fracture healing, and its abnormal expression is linked to bone diseases such as osteoporosis and sclerosing bone disease. It is a potential therapeutic target for metabolic bone disease treatment and fracture repair promotion.
SOST Recombinant Monoclonal Antibody (CSB-RA858415MA1HU)
Validated Data
IHC image of CSB-RA858415MA1HU diluted at 1:100 and staining in paraffin-embedded human kidney tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a Goat anti-human polymer IgG labeled by HRP and visualized using 0.05% DAB.
IHC image of CSB-RA858415MA1HU diluted at 1:100 and staining in paraffin-embedded human liver tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a Goat anti-human polymer IgG labeled by HRP and visualized using 0.05% DAB.
Human Sclerostin(SOST) ELISA Kit (CSB-E13146h)
Validated Data
Code: CSB-E13146h
Size: 96T,5×96T,10×96T
Sensitivity: 7.8 pg/mL
Detection Range: 31.25 pg/mL-2000 pg/mL
These standard curves are provided for demonstration only. A standard curve should be generated for each set of samples assayed.
The following SOST reagents supplied by CUSABIO are manufactured under a strict quality control system. Multiple applications have been validated and solid technical support is offered.
SOST Antibodies for Homo sapiens (Human)
Code | Product Name | Species Reactivity | Application |
---|---|---|---|
CSB-PA858415ESR1HU | SOST Antibody | Human | ELISA, IHC |
CSB-PA858415ESR2HU | SOST Antibody | Human | ELISA, WB, IHC |
CSB-PA020254 | SOST Antibody | Human | WB, ELISA |
CSB-RA858415MA1HU | SOST Recombinant Monoclonal Antibody | Human | ELISA, IHC |
SOST Antibodies for Rattus norvegicus (Rat)
Code | Product Name | Species Reactivity | Application |
---|---|---|---|
CSB-PA859165ZA01RA | Sost Antibody | Rattus norvegicus | ELISA, WB (ensure identification of antigen) |
SOST Proteins for Mus musculus (Mouse)
Code | Product Name | Source |
---|---|---|
CSB-YP858168MO CSB-EP858168MO CSB-EP858168MO-B |
Recombinant Mouse Sclerostin (Sost) | Yeast E.coli In Vivo Biotinylation in E.coli |
CSB-BP858168MO | Recombinant Mouse Sclerostin (Sost) | Baculovirus |
CSB-MP858168MO | Recombinant Mouse Sclerostin (Sost) | Mammalian cell |
SOST Proteins for Chlorocebus aethiops (Green monkey) (Cercopithecus aethiops)
Code | Product Name | Source |
---|---|---|
CSB-YP858374DSU CSB-EP858374DSU CSB-BP858374DSU CSB-MP858374DSU CSB-EP858374DSU-B |
Recombinant Chlorocebus aethiops Sclerostin (SOST) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
SOST Proteins for Homo sapiens (Human)
Code | Product Name | Source |
---|---|---|
CSB-YP858415HU CSB-EP858415HU CSB-BP858415HU CSB-MP858415HU CSB-EP858415HU-B |
Recombinant Human Sclerostin (SOST) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
CSB-MP858415HU-B | Recombinant Human Sclerostin (SOST), Biotinylated | Mammalian cell |
SOST Proteins for Rattus norvegicus (Rat)
Code | Product Name | Source |
---|---|---|
CSB-YP859165RA CSB-EP859165RA-B |
Recombinant Rat Sclerostin (Sost) | Yeast In Vivo Biotinylation in E.coli |
CSB-EP859165RA | Recombinant Rat Sclerostin (Sost) | E.coli |
CSB-BP859165RA | Recombinant Rat Sclerostin (Sost) | Baculovirus |
CSB-MP859165RA | Recombinant Rat Sclerostin (Sost) | Mammalian cell |
SOST Proteins for Bos taurus (Bovine)
Code | Product Name | Source |
---|---|---|
CSB-YP860205BO CSB-EP860205BO CSB-BP860205BO CSB-MP860205BO CSB-EP860205BO-B |
Recombinant Bovine Sclerostin (SOST) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
SOST ELISA Kit for Homo sapiens (Human)
Code | Product Name | Sample Types | Sensitivity |
---|---|---|---|
CSB-E13146h | Human Sclerostin(SOST) ELISA Kit | serum, plasma, tissue homogenates | 7.8 pg/mL |
SOST ELISA Kit for Rattus norvegicus (Rat)
Code | Product Name | Sample Types | Sensitivity |
---|---|---|---|
CSB-EL022415RA | Rat Sclerostin(SOST) ELISA kit | serum, plasma, tissue homogenates | 4.68 pg/mL |