Recombinant Bovine Toll-like receptor 2 (TLR2), partial

Code CSB-YP023601BO
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Source Yeast
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Code CSB-EP023601BO
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Source E.coli
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Code CSB-EP023601BO-B
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Source E.coli
Conjugate Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
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Code CSB-BP023601BO
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Source Baculovirus
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Code CSB-MP023601BO
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Source Mammalian cell
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Product Details

Purity
>85% (SDS-PAGE)
Target Names
TLR2
Uniprot No.
Alternative Names
TLR2; Toll-like receptor 2; EC 3.2.2.6; CD antigen CD282
Species
Bos taurus (Bovine)
Protein Length
Partial
Tag Info
Tag type will be determined during the manufacturing process.
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
Form
Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
Buffer before Lyophilization
Tris/PBS-based buffer, 6% Trehalose, pH 8.0
Reconstitution
We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
Troubleshooting and FAQs
Storage Condition
Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Shelf Life
The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
Lead Time
Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
Notes
Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet
Please contact us to get it.

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Target Background

Function
Cooperates with LY96 to mediate the innate immune response to bacterial lipoproteins and other microbial cell wall components. Cooperates with TLR1 or TLR6 to mediate the innate immune response to bacterial lipoproteins or lipopeptides. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. May also promote apoptosis in response to lipoproteins. Forms activation clusters composed of several receptors depending on the ligand, these clusters trigger signaling from the cell surface and subsequently are targeted to the Golgi in a lipid-raft dependent pathway. Forms the cluster TLR2:TLR6:CD14:CD36 in response to diacylated lipopeptides and TLR2:TLR1:CD14 in response to triacylated lipopeptides.
Gene References into Functions
  1. results suggest that polymorphisms in the TLR2 gene might not play a significant role in the BTB risk in Chinese Holstein cattle PMID: 28413050
  2. Transcription levels of TLR2, TLR4, and CD14 in Holstein cows with retained placenta significantly decreased between the first and the seventh day postpartum. PMID: 26777563
  3. We structurally defined with 5'-RACE experiments three promoters (P1-3) controlling TLR2 expression in udder, liver and other tissues of cows suffering from E. coli mastitis. PMID: 26235600
  4. TLR2 and TLR4 mediate innate response against Cryptosporidium parvum in bovine intestinal epithelial cells. PMID: 26048276
  5. positive correlation between lower neutrophil apoptosis and higher expression of TLR2 and TLR4 with the formation of NETs and change in surface architecture. PMID: 24915786
  6. TLR2, TLR1, and TLR6 haev roles in innate immunity and initiate inflammatory responses to bacterial lipopeptides by epithelial and stromal cells of bovine endometrium PMID: 24437488
  7. Data suggest that granulosa cells from dominant follicles express functional TLR2 and TLR4; granulosa cells appear to participate in innate immunity by responding to bacterial lipopolysaccharides/lipopeptides via TLR2 and TLR4 signaling pathways. PMID: 23825132
  8. The expressions of host TLR2 and 4 genes were significantly higher in acidosis-resistant steers compared to those in acidosis-susceptible steers. PMID: 22622335
  9. Whereas previous results regarding the TLR1 gene were not corroborated, a risk haplotype was detected in TLR2; however, its low frequency indicates that this detected association should be interpreted with caution. PMID: 21700053
  10. The identification of antibodies specific for bovine and ovine TLR2 will facilitate studies of the role of this important pattern recognition receptors in the initiation of immune responses to important pathogens. PMID: 21067818
  11. ALOX5AP, CPNE3, IL1R2, IL6, TLR2, TLR4, and THY1 were upregulated in blood polymorphonuclear cells in negative energy balance versus positive energy balance cows. PMID: 20072847
  12. This study showed that TLR1 and TLR2 together are necessary for the recognition of triacylated lipopeptides. PMID: 20167196
  13. The functional studies suggest that genetic polymorphisms in bovine TLR2 which result in higher macrophage activity may contribute to enhanced T cell activation and a lower susceptibility to paratuberculosis in cattle. PMID: 20005587
  14. fine mapping of bovine toll-like receptor 4 and toll-like receptor 2 regions PMID: 12584610
  15. mRNA abundances of TLR9, TLR2, and TLR4 together with those of beta-defensin 5 (BNBD5), an early bactericidal effector molecule of the innate system, in healthy and infected mammary glands PMID: 14715566
  16. Microcrystals of calcium pyrophosphate dihydrate and monosodium urate use TLR2-mediated signaling in chondrocytes to trigger NO generation. PMID: 15814732
  17. both S. aureus and E. coli pathogens activate equally well bovine TLR2 and TLR4 receptors to induce NF-kappaB activation PMID: 17936907
  18. This study indicates that SNP c.3020A>T might play a role in the host response against mastitis and further detailed studies are needed to understand its functional mechanisms. PMID: 18005441
  19. A combined linkage and linkage disequilibrium method was used to investigate possible associations between the TLR2 and THR4 genes and mastitis susceptibility recorded in the Norwegian Red cattle population. PMID: 18363976
  20. Analysis of sequence variability and protein domain architectures for bovine peptidoglycan recognition protein 1 and Toll-like receptors 2 and 6. PMID: 18639626
  21. Three missense mutations at T385 G, G398A, and G1884A were detected in the coding region that encoded extracellular domain. PMID: 19544205

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Subcellular Location
Membrane; Single-pass type I membrane protein. Cytoplasmic vesicle, phagosome membrane; Single-pass type I membrane protein. Membrane raft.
Protein Families
Toll-like receptor family
Database Links
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